Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease

被引:70
作者
Eckert, LO
Hawes, SE
WolnerHanssen, P
Money, DM
Peeling, RW
Brunham, RC
Stevens, CE
Eschenbach, DA
Stamm, WE
机构
[1] UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98104
[2] UNIV LUND HOSP,DEPT OBSTET & GYNECOL,S-22185 LUND,SWEDEN
[3] UNIV BRITISH COLUMBIA,DEPT OBSTET & GYNECOL,VANCOUVER,BC V5Z 1M9,CANADA
[4] UNIV MANITOBA,NATL LAB SEXUALLY TRANSMITTED DIS,LAB CTR DIS CONTROL,WINNIPEG,MB,CANADA
[5] UNIV MANITOBA,DEPT MED MICROBIOL,WINNIPEG,MB,CANADA
关键词
D O I
10.1086/516479
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A cross-sectional study of 306 women was done to correlate antibody to the chlamydial hsp60 (Chsp60) with epidemiologic, serologic, and laparoscopic findings of women with and without pelvic inflammatory disease (PID). Of the 306 women, 150 had confirmed PID by laparoscopic (n = 69) or histologic (n = 81) criteria, and 156 sexually transmitted disease clinic attendees without clinical PID did (n = 94) or did not (n = 62) have chlamydia. In multivariate analyses, Chsp60 antibody was independently associated with confirmed PID, age > 20 years, nonwhite race, > 10 lifetime sex partners, current oral contraceptive use, and IBG antibody titers; it was not associated with a positive Chlamydia trachomatis culture. Among the 69 women with laparoscopic evidence of PID, the highest level of Chsp60 antibody (optical density > 1.0) was found in 8 (80%) of 10 women with occluded tubes, compared with 11 (19%) of 58 with patent tubes (P < .001). We conclude that antibody to Chsp60 was significantly correlated with risk factors for PID, confirmed PID, and occluded fallopian tubes but not with acute C. trachomatis infection without PID.
引用
收藏
页码:1453 / 1458
页数:6
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