Elevated protein kinase CK2 activity in chromatin of head and neck tumors: Association with malignant transformation

被引：141

作者：

Faust, RA

Gapany, M

Tristani, P

Davis, A

Adams, GL

Ahmed, K

机构：

[1] VET ADM MED CTR,CELLULAR & MOLEC BIOCHEM RES LAB 151,MINNEAPOLIS,MN 55417

[2] UNIV MINNESOTA,DEPT OTOLARYNGOL,MINNEAPOLIS,MN 55417

[3] UNIV MINNESOTA,CANC RES CTR,MINNEAPOLIS,MN 55455

[4] UNIV MINNESOTA,LAB MED & PATHOL,MINNEAPOLIS,MN 55417

来源：

CANCER LETTERS | 1996年 / 101卷 / 01期

关键词：

protein kinase CK2 activity; chromatin; head and neck tumors;

D O I：

10.1016/0304-3835(96)04110-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We hypothesized that malignant transformation of normal mucosa of the upper aerodigestive tract to squamous cell carcinoma of the head and neck (SCCHN) might be associated with altered CK2 activity in the chromatin compartment of these tumors. We measured CK2 activity in the cytosol and chromatin of 7 surgical specimens of SCCHN, and 5 specimens of normal oropharyngeal mucosa from non-smokers/non-drinkers. CK2 activity in SCCHN tumors was significantly elevated in both the nuclear chromatin (P < 0.0005) and cytosolic (P < 0.04) compartments relative to normal mucosa. These data suggest that activation or dysregulation of the chromatin-associated CK2 signal may play a role in the pathobiology of SCCHN.

引用

页码：31 / 35

页数：5

共 18 条

[1] ASSOCIATION OF CASEIN KINASE-2 WITH NUCLEAR CHROMATIN IN RELATION TO ANDROGENIC REGULATION OF RAT PROSTATE [J].