New Concepts in Atrial Fibrillation: Neural Mechanisms and Calcium Dynamics

被引：25

作者：

Chou, Chung-Chuan ^{[1
]}

Chen, Peng-Sheng ^{[2
]}

机构：

[1] Chang Gung Mem Hosp, Sect Cardiol 2, Taipei 10591, Taiwan

[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

来源：

CARDIOLOGY CLINICS | 2009年 / 27卷 / 01期

关键词：

Atrium; Calcium; Fibrillation; Nervous system; Autonomic; CONGESTIVE-HEART-FAILURE; INDUCED TRIGGERED ACTIVITY; CANINE PULMONARY VEINS; AUTONOMIC TONE; THORACIC VEINS; CONDUCTION SYSTEM; SYMPATHETIC HYPERINNERVATION; RYANODINE RECEPTOR; CATHETER ABLATION; STELLATE GANGLION;

D O I：

10.1016/j.ccl.2008.09.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) is a complex arrhythmia with multiple possible mechanisms. It requires a trigger for initiation and a favorable substrate for maintenance. Pulmonary vein myocardial sleeves have the potential to generate spontaneous activity, and this arrhythmogenic activity is surfaced by modulation of intracellular calcium dynamics. Direct autonomic nerve recordings in canine models show that simultaneous sympathovagal discharges are the most common triggers of paroxysmal atrial tachycardia and paroxysmal AF. Autonomic modulation as a potential therapeutic strategy has been targeted clinically and experimentally, but its effectiveness as an adjunctive therapeutic modality to catheter ablation of AF has been inconsistent. Further studies are warranted before application can be widely implied for therapies of clinical AF.

引用

页码：35 / +

页数：10

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