Eudesmin inhibits tumor necrosis factor-α production and T cell proliferation

被引：23

作者：

Cho, JY

Yoo, ES

Baik, KU

Park, MH

机构：

[1] UCL, Sch Med, Windeyer Inst Med Sci, Dept Immunol, London W1P 6DB, England

[2] Daewoong Pharmaceut Co Ltd, R&D Ctr, Songnam 462120, Kyunggi Do, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1999年 / 22卷 / 04期

关键词：

eudesmin; Magnolia fargessi; tumor necrosis factor (TNF)-alpha; lymphocyte proliferation;

D O I：

10.1007/BF02979056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Possible antiinflammatory effects of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)-alpha production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages. The compound significantly inhibited TNF-alpha production by lipopolysaccharide (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity suggesting that eudesmin may inhibit TNF-alpha production without any interference of normal cell function. It also significantly attenuated T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner.

引用

页码：348 / 353

页数：6

共 30 条

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