Effects of recombinant leptin therapy in a child with congenital leptin deficiency

被引：1356

作者：

Farooqi, IS

Jebb, SA

Langmack, G

Lawrence, E

Cheetham, CH

Prentice, AM

Hughes, IA

McCamish, MA

O'Rahilly, S

机构：

[1] Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

[2] Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England

[3] Addenbrookes Hosp, Dept Paediat, Cambridge CB2 2QQ, England

[4] MRC, Dunn Clin Nutr Unit, Cambridge, England

[5] Amgen Inc, Thousand Oaks, CA 91320 USA

[6] Wycombe Hosp, Dept Paediat, High Wycombe, Bucks, England

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1999年 / 341卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1056/NEJM199909163411204

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

[No abstract available]

引用

页码：879 / 884

页数：6

共 31 条

[1]

Leptin accelerates the onset of puberty in normal female mice [J].

Ahima, RS ;

Dushay, J ;

Flier, SN ;

Prabakaran, D ;

Flier, JS .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (03) :391-395

[2]

GONADOTROPIN-RELEASING-HORMONE PULSE-GENERATOR ACTIVITY DURING PUBERTAL TRANSITION IN GIRLS - PULSATILE AND DIURNAL PATTERNS OF CIRCULATING GONADOTROPINS [J].

APTER, D ;

BUTZOW, TL ;

LAUGHLIN, GA ;

YEN, SSC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (04) :940-949

[3]

Leptin is a metabolic signal to the reproductive system [J].

Barash, IA ;

Cheung, CC ;

Weigle, DS ;

Ren, HP ;

Kabigting, EB ;

Kuijper, JL ;

Clifton, DK ;

Steiner, RA .

ENDOCRINOLOGY, 1996, 137 (07) :3144-3147

[4]

GENETICALLY TRANSMITTED OBESITY IN RODENTS [J].

BRAY, GA ;

YORK, DA .

PHYSIOLOGICAL REVIEWS, 1971, 51 (03) :598-+

[5]

Butler MG, 1998, AM J MED GENET, V75, P7, DOI 10.1002/(SICI)1096-8628(19980106)75:1<7::AID-AJMG3>3.0.CO

[6]

2-T

[7]

RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS [J].

CAMPFIELD, LA ;

SMITH, FJ ;

GUISEZ, Y ;

DEVOS, R ;

BURN, P .

SCIENCE, 1995, 269 (5223) :546-549

[8]

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin [J].

Chehab, FE ;

Lim, ME ;

Lu, RH .

NATURE GENETICS, 1996, 12 (03) :318-320

[9]

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction [J].

Clément, K ;

Vaisse, C ;

Lahlou, N ;

Cabrol, S ;

Pelloux, V ;

Cassuto, D ;

Gourmelen, M ;

Dina, C ;

Chambaz, J ;

Lacorte, JM ;

Basdevant, A ;

Bougneres, P ;

Lebouc, Y ;

Froguel, P ;

Guy-Grand, B .

NATURE, 1998, 392 (6674) :398-401

[10]

Serum immunoreactive leptin concentrations in normal-weight and obese humans [J].

Considine, RV ;

Sinha, MK ;

Heiman, ML ;

Kriauciunas, A ;

Stephens, TW ;

Nyce, MR ;

Ohannesian, JP ;

Marco, CC ;

McKee, LJ ;

Bauer, TL ;

Caro, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :292-295

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