Setting reaction of α-TCP spheres and an acidic calcium phosphate solution for the fabrication of fully interconnected macroporous calcium phosphate

被引：24

作者：

Pham Trung Kien ^{[1
]}

Ishikawa, Kunio ^{[1
]}

Tsuru, Kanji ^{[1
]}

机构：

[1] Kyushu Univ, Fac Dent Sci, Dept Biomat, Higashi Ku, Fukuoka 8128582, Japan

来源：

CERAMICS INTERNATIONAL | 2015年 / 41卷 / 10期

关键词：

alpha-TCP sphere; Acidic calcium phosphate solution; Brushite; Calcium phosphate cement; BETA-TRICALCIUM PHOSPHATE; HYDROXYAPATITE FOAM; COMPOSITIONAL PROPERTIES; SINTERING TEMPERATURE; POROUS HYDROXYAPATITE; CEMENT; REGENERATION; OSTEOGENESIS; DISSOLUTION; SCAFFOLDS;

D O I：

10.1016/j.ceramint.2015.07.146

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

081705 [工业催化]; 082905 [生物质能源与材料];

摘要：

Interconnected macroporous calcium phosphate has attracted attention as an artificial bone substitute as well as a scaffold for tissue engineering. In this investigation, a setting reaction between alpha-tricalcium phosphate (alpha-TCP) spheres and an acidic calcium phosphate solution (0.2 mol/L monocalcium phosphate monohydrate - 0.1 mol/L phosphoric acid) was studied to assess the feasibility of fabricating fully interconnected macroporous calcium phosphate. When 1.3 mm-diameter alpha-TCP spheres were exposed to an acidic calcium phosphate solution, brushite (dicalcium phosphate dihydrate) was formed on the surface of the alpha-TCP spheres. The precipitated brushite crystals interlocked with one another and bridged the alpha-TCP spheres, resulting in a 10 min setting reaction at 37 degrees C that produced fully interconnected macroporous calcium phosphate. The resultant calcium phosphate macroporous structure had a porosity of 49.7 +/- 2.5% and an average pore size of 312 +/- 160 mu m. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

引用

页码：13525 / 13531

页数：7

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