Chemokine receptor expression on MBP-reactive T cells:: CXCR6 is a marker of IFN-γ-producing effector cells

被引：29

作者：

Calabresi, PA

Yun, SH

Allie, R

Whartenby, KA

机构：

[1] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

[2] Johns Hopkins Med Inst, Div Immunol & Hematopoiesis, Baltimore, MD 21205 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 127卷 / 1-2期

关键词：

chemokine receptors; MBP; Th1/Th2; multiple sclerosis;

D O I：

10.1016/S0165-5728(02)00106-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNgamma, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7(-)/CD45RA(-) T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tern phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS). (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：96 / 105

页数：10

共 43 条

[1] Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1 [J].