HEART FAILURE IN 2013 Continue what we are doing to treat HF, but do it better

被引：13

作者：

Cohn, Jay N. ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Div Cardiovasc, Minneapolis, MN 55455 USA

来源：

NATURE REVIEWS CARDIOLOGY | 2014年 / 11卷 / 02期

关键词：

PRESERVED EJECTION FRACTION; CARDIAC-RESYNCHRONIZATION THERAPY; EXERCISE CAPACITY; INHIBITION; SPIRONOLACTONE; TRIAL;

D O I：

10.1038/nrcardio.2013.212

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

In 2013, clinical trials in heart failure focused on drugs and devices that might improve treatment of symptomatic patients beyond standard therapy. None achieved this aim. Therefore, future efforts should emphasize increased adherence to current, evidence-based therapy, and trials might better address efforts to prevent, rather than treat, heart failure. © 2014 Macmillan Publishers Limited. All rights reserved.

引用

页码：69 / 70

页数：2

共 10 条

[1]

Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure [J].

Bristow, MR ;

Saxon, LA ;

Boehmer, J ;

Krueger, S ;

Kass, DA ;

De Marco, T ;

Carson, P ;

DiCarlo, L ;

DeMets, D ;

White, BG ;

DeVries, DW ;

Feldman, AM .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2140-2150

[2]

Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Renal Dysfunction The ROSE Acute Heart Failure Randomized Trial [J].

Chen, Horng H. ;

Anstrom, Kevin J. ;

Givertz, Michael M. ;

Stevenson, Lynne W. ;

Semigran, Marc J. ;

Goldsmith, Steven R. ;

Bart, Bradley A. ;

Bull, David A. ;

Stehlik, Josef ;

LeWinter, Martin M. ;

Konstam, Marvin A. ;

Huggins, Gordon S. ;

Rouleau, Jean L. ;

O'Meara, Eileen ;

Tang, W. H. Wilson ;

Starling, Randall C. ;

Butler, Javed ;

Deswal, Anita ;

Felker, G. Michael ;

O'Connor, Christopher M. ;

Bonita, Raphael E. ;

Margulies, Kenneth B. ;

Cappola, Thomas P. ;

Ofili, Elizabeth O. ;

Mann, Douglas L. ;

Davila-Roman, Victor G. ;

McNulty, Steven E. ;

Borlaug, Barry A. ;

Velazquez, Eric J. ;

Lee, Kerry L. ;

Shah, Monica R. ;

Hernandez, Adrian F. ;

Braunwald, Eugene ;

Redfield, Margaret M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 310 (23) :2533-2543

[3]

STRUCTURAL BASIS FOR HEART-FAILURE - VENTRICULAR REMODELING AND ITS PHARMACOLOGICAL INHIBITION [J].

COHN, JN .

CIRCULATION, 1995, 91 (10) :2504-2507

[4]

Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction The Aldo-DHF Randomized Controlled Trial [J].

Edelmann, Frank ;

Wachter, Rolf ;

Schmidt, Albrecht G. ;

Kraigher-Krainer, Elisabeth ;

Colantonio, Caterina ;

Kamke, Wolfram ;

Duvinage, Andre ;

Stahrenberg, Raoul ;

Durstewitz, Kathleen ;

Loeffler, Markus ;

Duengen, Hans-Dirk ;

Tschoepe, Carsten ;

Herrmann-Lingen, Christoph ;

Halle, Martin ;

Hasenfuss, Gerd ;

Gelbrich, Goetz ;

Pieske, Burkert .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (08) :781-791

[5]

Effect of If-Channel Inhibition on Hemodynamic Status and Exercise Tolerance in Heart Failure With Preserved Ejection Fraction [J].

Kosmala, Wojciech ;

Holland, David J. ;

Rojek, Aleksandra ;

Wright, Leah ;

Przewlocka-Kosmala, Monika ;

Marwick, Thomas H. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (15) :1330-1338

[6]

Pfeffer M. A., AM HEART ASS SCI SES

[7]

The effect of spironolactone on morbidity and mortality in patients with severe heart failure [J].

Pitt, B ;

Zannad, F ;

Remme, WJ ;

Cody, R ;

Castaigne, A ;

Perez, A ;

Palensky, J ;

Wittes, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (10) :709-717

[8]

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction A Randomized Clinical Trial [J].

Redfield, Margaret M. ;

Chen, Horng H. ;

Borlaug, Barry A. ;

Semigran, Marc J. ;

Lee, Kerry L. ;

Lewis, Gregory ;

LeWinter, Martin M. ;

Rouleau, Jean L. ;

Bull, David A. ;

Mann, Douglas L. ;

Deswal, Anita ;

Stevenson, Lynne W. ;

Givertz, Michael M. ;

Ofili, Elizabeth O. ;

O'Connor, Christopher M. ;

Felker, G. Michael ;

Goldsmith, Steven R. ;

Bart, Bradley A. ;

McNulty, Steven E. ;

Ibarra, Jenny C. ;

Lin, Grace ;

Oh, Jae K. ;

Patel, Manesh R. ;

Kim, Raymond J. ;

Tracy, Russell P. ;

Velazquez, Eric J. ;

Anstrom, Kevin J. ;

Hernandez, Adrian F. ;

Mascette, Alice M. ;

Braunwald, Eugene .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (12) :1268-1277

[9]

Cardiac-Resynchronization Therapy in Heart Failure with a Narrow QRS Complex [J].

Ruschitzka, Frank ;

Abraham, William T. ;

Singh, Jagmeet P. ;

Bax, Jeroen J. ;

Borer, Jeffrey S. ;

Brugada, Josep ;

Dickstein, Kenneth ;

Ford, Ian ;

Gorcsan, John ;

Gras, Daniel ;

Krum, Henry ;

Sogaard, Peter ;

Holzmeister, Johannes .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (15) :1395-1405

[10]

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study [J].

Swedberg, Karl ;

Komajda, Michel ;

Boehm, Michael ;

Borer, Jeffrey S. ;

Ford, Ian ;

Dubost-Brama, Ariane ;

Lerebours, Guy ;

Tavazzi, Luigi .

LANCET, 2010, 376 (9744) :875-885

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