Eye color and the prediction of complex phenotypes from genotypes

被引:190
作者
Liu, Fan [1 ]
van Duijn, Kate [1 ]
Vingerling, Johannes R. [2 ,3 ]
Hofman, Albert [2 ]
Uitterlinden, Andre G. [2 ,4 ]
Janssens, A. Cecile J. W. [2 ]
Kayser, Manfred [1 ]
机构
[1] Erasmus Univ, Med Ctr Rotterdam, Dept Forens Mol Biol, NL-3000 CA Rotterdam, Netherlands
[2] Erasmus Univ, Med Ctr Rotterdam, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands
[3] Erasmus Univ, Med Ctr Rotterdam, Dept Ophthalmol, NL-3000 CA Rotterdam, Netherlands
[4] Erasmus Univ, Med Ctr Rotterdam, Genet Lab, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands
关键词
GENETIC-DETERMINANTS; HUMAN PIGMENTATION; HERC2; POLYMORPHISM; HAPLOTYPE; EUROPEANS; HEALTH;
D O I
10.1016/j.cub.2009.01.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:R192 / R193
页数:2
相关论文
共 16 条
[1]   The impact of genetics and genomics on public health [J].
Brand, Angela ;
Brand, Helmut ;
den Baeumen, Tobias Schulte .
EUROPEAN JOURNAL OF HUMAN GENETICS, 2008, 16 (01) :5-13
[2]   A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation [J].
Duffy, David L. ;
Montgomery, Grant W. ;
Chen, Wei ;
Zhao, Zhen Zhen ;
Le, Lien ;
James, Michael R. ;
Hayward, Nicholas K. ;
Martin, Nicholas G. ;
Sturm, Richard A. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) :241-252
[3]   Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression [J].
Eiberg, Hans ;
Troelsen, Jesper ;
Nielsen, Mette ;
Mikkelsen, Annemette ;
Mengel-From, Jonas ;
Kjaer, Klaus W. ;
Hansen, Lars .
HUMAN GENETICS, 2008, 123 (02) :177-187
[4]   Multilocus OCA2 genotypes specify human iris colors [J].
Frudakis, Tony ;
Terravainen, Timothy ;
Thomas, Matthew .
HUMAN GENETICS, 2007, 122 (3-4) :311-326
[5]   Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation [J].
Graf, J ;
Hodgson, R ;
van Daal, A .
HUMAN MUTATION, 2005, 25 (03) :278-284
[6]   Genomic profiling to promote a healthy lifestyle: not ready for prime time [J].
Haga, SB ;
Khoury, MJ ;
Burke, W .
NATURE GENETICS, 2003, 34 (04) :347-350
[7]   The Rotterdam Study: Objectives and design update [J].
Hofman, Albert ;
Breteler, Monique M. B. ;
van Duijn, Cornelia M. ;
Krestin, Gabriel P. ;
Pols, Huibert A. ;
Stricker, Bruno H. Ch. ;
Tiemeier, Henning ;
Uitterlinden, Andre G. ;
Vingerling, Johannes R. ;
Witteman, Jacqueline C. M. .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2007, 22 (11) :819-829
[8]   Genotype, haplotype and copy-number variation in worldwide human populations [J].
Jakobsson, Mattias ;
Scholz, Sonja W. ;
Scheet, Paul ;
Gibbs, J. Raphael ;
VanLiere, Jenna M. ;
Fung, Hon-Chung ;
Szpiech, Zachary A. ;
Degnan, James H. ;
Wang, Kai ;
Guerreiro, Rita ;
Bras, Jose M. ;
Schymick, Jennifer C. ;
Hernandez, Dena G. ;
Traynor, Bryan J. ;
Simon-Sanchez, Javier ;
Matarin, Mar ;
Britton, Angela ;
van de Leemput, Joyce ;
Rafferty, Ian ;
Bucan, Maja ;
Cann, Howard M. ;
Hardy, John A. ;
Rosenberg, Noah A. ;
Singleton, Andrew B. .
NATURE, 2008, 451 (7181) :998-1003
[9]   A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions [J].
Janssens, A. Cecile J. W. ;
Gwinn, Marta ;
Bradley, Linda A. ;
Oostra, Ben A. ;
van Duijn, Cornelia M. ;
Khoury, Muin J. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (03) :593-599
[10]   Genome-based prediction of common diseases: advances and prospects [J].
Janssens, A. Cecile J. W. ;
van Duijn, Cornelia M. .
HUMAN MOLECULAR GENETICS, 2008, 17 :R166-R173