Integrated regulation of intestinal epithelial transport: Intercellular and intracellular pathways

被引:43
作者
Barrett, KE [1 ]
机构
[1] UNIV CALIF SAN DIEGO, SCH MED, DEPT MED, SAN DIEGO, CA 92103 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 1997年 / 272卷 / 04期
关键词
chloride secretion; bicarbonate secretion; mast cells; enteric nerves; epidermal growth factor; inositol phosphates; phosphatidylinositol; 3-kinase;
D O I
10.1152/ajpcell.1997.272.4.C1069
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The intestinal epithelium is an important site of active solute transport processes. Such processes include the secretion of electrolytes into the lumen, predominantly chloride and bicarbonate. These secretory mechanisms subserve a variety of functions, both physiological and pathophysiological, including maintenance of the fluidity of intestinal contents and mucosal defense. Both chloride and bicarbonate secretion are the subject of integrated regulatory mechanisms at both the intercellular and intracellular levels. The goal of this article is to discuss data that exemplify these two levels of regulation, which have been the subject of research in my laboratory. It is likely that some of these principles are also broadly applicable to secretory epithelial cells outside of the intestinal tract, such as those in the airway I also discuss the ways in which we believe these regulatory mechanisms are involved not only in intestinal physiology but also perhaps in the pathogenesis of specific disease states.
引用
收藏
页码:C1069 / C1076
页数:8
相关论文
共 40 条
[1]  
BARRETT KE, 1993, AM J PHYSIOL, V265, pC859
[2]  
BARRETT KE, 1991, J IMMUNOL, V147, P959
[3]   IMMUNE-RELATED INTESTINAL CHLORIDE SECRETION .2. EFFECT OF ADENOSINE ON T84 CELL-LINE [J].
BARRETT, KE ;
COHN, JA ;
HUOTT, PA ;
WASSERMAN, SI ;
DHARMSATHAPHORN, K .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (05) :C902-C912
[4]  
BARRETT KE, 1991, PROGR INFLAMM BOWEL, V12, P8
[5]  
BARRETT KE, 1988, IMMUNOLOGY GASTROINT, P65
[6]  
BORON WF, 1994, J EXP BIOL, V196, P347
[7]  
Castro Gilbert A., 1994, P709
[8]   Cloning of an epithelial chloride channel from bovine trachea [J].
Cunningham, SA ;
Awayda, MS ;
Bubien, JK ;
Ismailov, II ;
Arrate, MP ;
Berdiev, BK ;
Benos, DJ ;
Fuller, CM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (52) :31016-31026
[9]   MULTIPLE CALCIUM-MEDIATED EFFECTOR MECHANISMS REGULATE CHLORIDE SECRETORY RESPONSES IN T84-CELLS [J].
DHARMSATHAPHORN, K ;
COHN, J ;
BEUERLEIN, G .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06) :C1224-C1230
[10]   A HUMAN COLONIC TUMOR-CELL LINE THAT MAINTAINS VECTORIAL ELECTROLYTE TRANSPORT [J].
DHARMSATHAPHORN, K ;
MCROBERTS, JA ;
MANDEL, KG ;
TISDALE, LD ;
MASUI, H .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (02) :G204-G208