Thymic microenvironments for T cell differentiation and selection

被引：119

作者：

Ladi, E ^{[1
]}

Yin, XY ^{[1
]}

Chtanova, T ^{[1
]}

Robey, EA ^{[1
]}

机构：

[1] Univ Calif Berkeley, Div Immunol, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 04期

关键词：

D O I：

10.1038/ni1323

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adult thymus provides a variety of specialized microenvironments that support and direct T cell differentiation and selection. In this review, we summarize recent advances in the understanding of the function of microenvironments in shaping a diverse T cell repertoire. In particular, we focus on how thymocytes move in and out of these specialized thymic compartments in response to homing signals, differential chemokine gradients and other factors that regulate T cell migration. In addition, we discuss the diverse developmental signals provided by these microenvironments that contribute to the generation of divergent T cell lineages.

引用

页码：338 / 343

页数：6

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