New labdane diterpenes from Leonurus cardiaca

被引：27

作者：

Agnihotri, Vijai K. ^{[1
]}

Elsohly, Hala N. ^{[1
]}

Smillie, Troy J. ^{[1
]}

Khan, Ikhlas A. ^{[1
,2
]}

Walker, Larry A. ^{[1
]}

机构：

[1] Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, Pharmaceut Sci Res Inst, University, MS 38677 USA

来源：

PLANTA MEDICA | 2008年 / 74卷 / 10期

基金：

美国农业部;

关键词：

Leonurus cardiaca; lamiaceae; labdane diterpenes;

D O I：

10.1055/s-2008-1081304

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Leonunis cardiaca L. has been used in oriental medicine against several types of disorders. The ethanolic extract of leaves of Leonurus cardiaca yielded three new labdane-type diterpenes: 15-O-ethylleopersin C (1), 15-O-methylleopersin C (2), and 15-epi-O-methylleopersin C (3). Their structures were determined using I D and 2 D NMR including H-1-H-1 COSY, HMQC, HMBC, and ROESY spectroscopic techniques. Compounds (1-3) were evaluated for in vitro antiplasmodial activity (D6 and W2 clones) and cytotoxicity (Vero cells).

引用

页码：1288 / 1290

页数：3

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