Heterogeneous aortic response to acute beta-adrenergic blockade in Marfan syndrome

被引:61
作者
Haouzi, A
Berglund, H
Pelikan, PCD
Maurer, G
Siegel, RJ
机构
[1] CEDARS SINAI MED CTR,DIV CARDIOL,LOS ANGELES,CA 90048
[2] HOP BRABOIS,DEPT CARDIOVASC SURG,LOS ANGELES,CA 90048
[3] UNIV CALIF LOS ANGELES,SCH MED,LOS ANGELES,CA
[4] ST JOHNS HOSP & HEART CTR,PACIFIC HEART INST,SANTA MONICA,CA
[5] UNIV VIENNA,DEPT CARDIOL,VIENNA,AUSTRIA
关键词
D O I
10.1016/S0002-8703(97)70248-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although prophylactic treatment with beta-blockers is used to retard aortic root dilatation in Marfan syndrome, it is not effective in all patients. To assess the effects of beta-adrenergic blockade on the aorta's elastic properties, aortic stiffness index and distensibility were calculated in 13 patients with Marfan syndrome and 10 control subjects before and after beta-adrenergic blockade. At baseline, patients with Marfan syndrome had a significantly increased stiffness index and decreased distensibility. After beta-adrenergic blockade, 8 patients with Marfan syndrome developed stiffness indexes and distensibility values that were closer to normal, whereas these variables deteriorated in 5 patients. Thus the benefit of beta-adrenergic blockade in Marfan syndrome may be the reduction in pulse pressure and myocardial contractility and also promotion of the elastic properties of the aorta. Moreover, the differential responses of aortic mechanics (normalizing or worsening) to beta-adrenergic blockade may possibly have implications for the prognosis in these patients.
引用
收藏
页码:60 / 63
页数:4
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