Investigation of erythrocyte membrane lipid peroxidation and antioxidant defense systems of patients with coronary artery disease (CAD) documented by angiography

被引：47

作者：

Akkus, I

Saglam, NI

Caglayan, O

Vural, H

Kalak, S

Saglam, M

机构：

[1] Selçuk University, School of Medicine, Department of Biochemistry, Konya

来源：

CLINICA CHIMICA ACTA | 1996年 / 244卷 / 02期

关键词：

coronary artery disease; erythrocyte; lipid peroxidation; superoxide dismutase; glutathione peroxidase; vitamin C;

D O I：

10.1016/0009-8981(95)06192-4

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

In the present study, erythrocyte membrane lipid peroxidation, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and serum vitamin C levels of subjects with and without coronary artery disease (CAD) documented by coronary angiography have been determined. Patients consisted of 42 subjects (31 male, 11 female) aged between 41 and 77 years and controls consisted of 35 subjects (21 male, 14 female) aged between 40 and 69 years. Erythrocyte lipid peroxidation of the patients was significantly higher (P < 0.005) whereas erythrocyte SOD, GSH-Px activities and serum vitamin C levels were lower than those of controls. Our results show significant alteration in erythrocyte membranes and anti-oxidant status of patients with CAD. However, whether such alterations are a primary cause or consequence of CAD and whether these alterations can be used in the diagnosis and management of the disease needs further investigation.

引用

页码：173 / 180

页数：8

共 38 条

[1] OXIDISABILITY OF LOW-DENSITY LIPOPROTEINS IN PATIENTS WITH CAROTID OR FEMORAL-ARTERY ATHEROSCLEROSIS [J].