NGF and BDNF increase the immunoreactivity of vesicular acetylcholine transporter in cultured neurons from the embryonic rat septum

被引：27

作者：

Takei, N

Kuramoto, H

Endo, Y

Hatanaka, H

机构：

[1] KYOTO INST TECHNOL,DEPT APPL BIOL,KYOTO 606,JAPAN

[2] OSAKA UNIV,INST PROT RES,SUITA,OSAKA 565,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 226卷 / 03期

关键词：

nerve growth factor; brain-derived neurotrophic factor; vesicular acetylcholine transporter; acetylcholine; immunocytochemistry;

D O I：

10.1016/S0304-3940(97)00284-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of vesicular acetylcholine transporter (VAChT), which transports ACh into synaptic vesicles, is coregulated with choline acetyltransferase (ChAT). Therefore, the effects of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) on the levels of VAChT in cultured neurons from the septum of embryonic rats were investigated by immunocytochemistry. NGF and BDNF increased the number of VAChT-immunoreactive neurons by approximately 1.5-fold and enhanced the immunoreactivity in each positive cell. These results suggest that the neurotrophins enhance not only synthesis but also storage of ACh in septal neurons. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：207 / 209

页数：3

共 15 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].