New hetero-oligomeric peptide nucleic acids with improved binding properties to complementary DNA

被引：47

作者：

Jordan, S

Schwemler, C

Kosch, W

Kretschmer, A

Stropp, U

Schwenner, E

Mielke, B

机构：

[1] Bayer AG, Central Research

[2] Bayer AG, Pharma Research Center

[3] Biotest AG, D-63303 Dreieich

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(97)00085-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hetero-oligomeric PNAs consisting of new monomeric building blocks and various amounts of N-(2-aminoethyl) glycine have been synthesized by solid-phase chemistry. Some of these new compounds show stronger binding to complementary DNA than the original PNAs, and are consequently very interesting candidates as antisense compounds for applications in therapy and in diagnostics. (C) 1997 Elsevier Science Ltd.

引用

页码：687 / 690

页数：4

共 20 条

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