The effects of several vasopressin receptor antagonists on normal intraocular pressure and the intraocular distribution of vasopressin receptor subtypes

被引：5

作者：

Naito, A

Kurasawa, T

Ohtake, Y

Toyoda, Y

Ezure, Y

Koike, K

Shigenobu, K

机构：

[1] Wakamoto Pharmaceut Co Ltd, Sagami Res Lab, Oi, Kanagawa 2580018, Japan

[2] Toho Univ, Sch Pharmaceut Sci, Chiba 2748510, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 02期

关键词：

vasopressin; vasopressin receptor; vasopressin receptor antagonist; intraocular pressure; mapping;

D O I：

10.1248/bpb.25.251

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present paper is to study the relation between vasopressin antagonism and the regulation of intraocular pressure (IOP). From the studies on the effect of several vasopressin receptor antagonists, VP-343, OPC-21268, YM087, OPC-31260 and SR121463, on normal IOP and the effect of VP-343 on pupil diameter in rabbit, it was shown that some vasopressin antagonists decreased normal IOP and VP-343 had no influence on pupil diameter. A vasopressin receptor mapping study in normal cynomolgus monkey eye revealed a high density binding site for a [H-3]vasopressin V-1 antagonist in the region of iris. These findings suggest that a vasopressin antagonist should decrease normal IOP without miosis and that vasopressin V, receptors are present in iris.

引用

页码：251 / 255

页数：5

共 16 条

[1] EFFECT OF WATER-INTAKE ON THE PROGRESSION OF CHRONIC-RENAL-FAILURE IN THE 5/6 NEPHRECTOMIZED RAT [J].