Urinary eosinophil protein X in relation to disease activity in childhood asthma

被引:47
作者
Lugosi, E [1 ]
Halmerbauer, G [1 ]
Frischer, T [1 ]
Koller, DY [1 ]
机构
[1] UNIV CHILDRENS HOSP, DIV ALLERGY & PULM, A-1090 VIENNA, AUSTRIA
关键词
asthma; children; eosinophil protein X (EPX); pulmonary function; urine;
D O I
10.1111/j.1398-9995.1997.tb02605.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The clinical use of urinary eosinophil protein X (U-EPX) measurements in monitoring inflammation in childhood asthma was investigated. U-EPX and pulmonary function were assessed in 80 children with bronchial asthma and 24 healthy, age-matched controls. In addition, 14 patients with asthma were re-examined after 1-2 months. U-EPX levels were increased in children with asthma compared with controls (median 68.4 vs 35.3 mu g/mmol creatinine; P<0.0001). In addition, U-EPX levels were higher in symptomatic than in asymptomatic patients (median 123.5 vs 48.9 mu g/mmol creatinine; P<0.0001) independent of treatment modalities (i.e., inhaled steroids or disodium cromoglycate) or atopy (median 65.1 vs 86.0 mu g/mmol creatinine). Furthermore, U-EPX levels were significantly correlated with pulmonary function. During the follow-up period, changes in U-EPX values were significantly related to changes in pulmonary function. In conclusion, our findings demonstrate that eosinophil activation can be measured in urine in childhood asthma. Concentrations of U-EPX are related to disease activity and pulmonary function, as shown in both cross-sectional and longitudinal analyses, but are independent of atopy and treatment modalities. Measurement of U-EPX may be useful in assessing the inflammatory process and therefore in the management of childhood asthma.
引用
收藏
页码:584 / 588
页数:5
相关论文
共 18 条
[1]  
AHLSTEDT S, 1992, Pharmaceutical Medicine (London), V6, P99
[2]  
*AM THOR SOC, 1987, AM REV RESPIR DIS, V2, P1285
[4]   SECRETION OF GRANULE PROTEINS FROM EOSINOPHILS AND NEUTROPHILS IS INCREASED IN ASTHMA [J].
CARLSON, M ;
HAKANSSON, L ;
PETERSON, C ;
STALENHEIM, G ;
VENGE, P .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1991, 87 (01) :27-33
[5]  
DAHL R, 1992, ASTHMA BASIC MECHANI, P111
[6]   THE GORDON PHENOMENON INDUCED BY THE EOSINOPHIL CATIONIC PROTEIN AND EOSINOPHIL PROTEIN-X [J].
FREDENS, K ;
DAHL, R ;
VENGE, P .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1982, 70 (05) :361-366
[7]   THE EOSINOPHIL AND BRONCHIAL-ASTHMA - CURRENT UNDERSTANDING [J].
GLEICH, GJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1990, 85 (02) :422-436
[8]  
Gotz M, 1993, Agents Actions Suppl, V40, P153
[9]  
HALLGREN R, 1991, CLIN IMPACT MONITORI, P119
[10]   EOSINOPHILIC ACTIVATION IN CYSTIC-FIBROSIS [J].
KOLLER, DY ;
GOTZ, M ;
EICHLER, I ;
URBANEK, R .
THORAX, 1994, 49 (05) :496-499