Isolation and Structure Elucidation of Pentahydroxyscirpene, a Trichothecene Fusarium Mycotoxin

被引：11

作者：

Fruhmann, Philipp ^{[1
]}

Mikula, Hannes ^{[1
]}

Wiesenberger, Gerlinde ^{[2
]}

Varga, Elisabeth ^{[3
,4
]}

Lumpi, Daniel ^{[1
]}

Stoeger, Berthold ^{[5
]}

Haeubl, Georg ^{[6
]}

Lemmens, Marc ^{[7
]}

Berthiller, Franz ^{[3
,4
]}

Krska, Rudolf ^{[3
,4
]}

Adam, Gerhard ^{[2
]}

Hametner, Christian ^{[1
]}

Froehlich, Johannes ^{[1
]}

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] Univ Nat Resources & Life Sci, Vienna BOKU, Dept Appl Genet & Cell Biol, A-3430 Tulln, Austria

[3] Univ Nat Resources & Life Sci, Vienna BOKU, Christian Doppler Lab Mycotoxin Metab, A-3430 Tulln, Austria

[4] Univ Nat Resources & Life Sci, Vienna BOKU, Ctr Analyt Chem, Dept Agrobiotechnol IFA Tulln, A-3430 Tulln, Austria

[5] Vienna Univ Technol, Inst Chem Technol & Analyt, A-1060 Vienna, Austria

[6] Romer Labs Div Holding GmbH, A-3430 Tulln, Austria

[7] Univ Nat Resources & Life Sci, Vienna BOKU, Inst Biotechnol Plant Prod, Dept Agrobiotechnol IFA Tulln, A-3430 Tulln, Austria

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 01期

关键词：

TOXICOLOGY;

D O I：

10.1021/np4008365

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY experiments supported by quantum chemical calculations. In vitro toxicity tests showed that pentahydroxyscirpene inhibits protein synthesis as do other trichothecenes.

引用

页码：188 / 192

页数：5

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