Iron metabolism meets signal transduction

被引：22

作者：

Anderson, GJ ^{[1
]}

Frazer, DM ^{[1
]}

机构：

[1] PO Royal Brisbane Hosp, Queensland Inst Med Res, Iron Metab Lab, Brisbane, Qld 4029, Australia

来源：

NATURE GENETICS | 2006年 / 38卷 / 05期

关键词：

D O I：

10.1038/ng0506-503

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutations in hemojuvelin disrupt its ability to stimulate expression of the iron regulatory peptide hepcidin and result in the severe iron loading disorder juvenile hemochromatosis. A new study shows that hemojuvelin acts through the multifunctional bone morphogenetic protein pathway to modulate hepcidin levels, providing new insights into communication within a key physiological pathway.

引用

页码：503 / 504

页数：2

共 15 条

[1] Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
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Huang, FW
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Andrews, NC
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[J]. NATURE GENETICS, 2006, 38 (05) : 531 - 539
[2] Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
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Frazer, DM
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Zhao, M
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Nemeth, E
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