Effect of amoxicillin-clavulanic acid on human fecal flora in a gnotobiotic mouse model assessed with fluorescence hybridization using group-specific 16S rRNA probes in combination with flow cytometry

被引：36

作者：

Barc, MC

Bourlioux, F

Rigottier-Gois, L

Charrin-Sarnel, C

Janoir, C

Boureau, H

Doré, JL

Collignon, A ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, Dept Microbiol, Unite INRA Ecosyst Microbien Digestif & Sante, F-92296 Chatenay Malabry, France

[2] INRA, Unite Ecol & Physiol Syst Digestif, F-78852 Jouy En Josas, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 04期

关键词：

D O I：

10.1128/AAC.48.4.1365-1368.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Predominant groups of bacteria from a human fecal flora-associated mouse model challenged with amoxicillin-clavulanic acid were quantified with fluorescence in situ hybridization combined with How cytometry using specific 16S rRNA targeted oligonucleotide probes. This approach provides a useful tool with high throughput to evaluate fecal microflora under antibiotic treatment.

引用

页码：1365 / 1368

页数：4

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