Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea

被引：32

作者：

Palmer, S ^{[1
]}

Cox, S ^{[1
]}

机构：

[1] KAROLINSKA INST,MICROBIOL & TUMOR BIOL CTR,STOCKHOLM,SWEDEN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 02期

关键词：

D O I：

10.1128/AAC.41.2.460

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The intracellular phosphorylation of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine was increased two- to threefold by the addition of hydroxyurea (HU) to the single drugs or to the two drugs in combination. The ratios of drug triphosphate to competing cellular deoxynucleoside triphosphate were increased two- to threefold for both 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of HU. These HU-induced increases in 3'-azido-3'-deoxythymidine and 3'-deoxy-3'-thiacytidine metabolism may further enhance the anti-human immunodeficiency virus activity of these two drugs.

引用

页码：460 / 464

页数：5

共 46 条

[1]

AGARWAL RP, 1994, BIOCHEM BIOPH RES CO, V250, P92

[2] PREFERENTIAL INCORPORATION OF NUCLEOSIDE ANALOGS AFTER TEMPLATE SWITCHING DURING HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE TRANSCRIPTION [J].

ARTS, EJ ;

WAINBERG, MA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (05) :1008-1016

[3] METABOLISM AND MECHANISM OF ANTIRETROVIRAL ACTION OF PURINE AND PYRIMIDINE-DERIVATIVES [J].

BALZARINI, J .

PHARMACY WORLD & SCIENCE, 1994, 16 (02) :113-126

[4]

BIANCHI V, 1986, J BIOL CHEM, V261, P6037

[5] CELLULAR-METABOLISM OF (-) ENANTIOMERIC 2'-DEOXY-3'-THIACYTIDINE [J].

CAMMACK, N ;

ROUSE, P ;

MARR, CLP ;

REID, PJ ;

BOEHME, RE ;

COATES, JAV ;

PENN, CR ;

CAMERON, JM .

BIOCHEMICAL PHARMACOLOGY, 1992, 43 (10) :2059-2064

[6] (-)-2'-DEOXY-3'-THIACYTIDINE IS A POTENT, HIGHLY SELECTIVE INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND TYPE-2 REPLICATION INVITRO [J].

COATES, JAV ;

CAMMACK, N ;

JENKINSON, HJ ;

JOWETT, AJ ;

JOWETT, MI ;

PEARSON, BA ;

PENN, CR ;

ROUSE, PL ;

VINER, KC ;

CAMERON, JM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (04) :733-739

[7] THE SEPARATED ENANTIOMERS OF 2'-DEOXY-3'-THIACYTIDINE (BCH-189) BOTH INHIBIT HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION INVITRO [J].

COATES, JAV ;

CAMMACK, N ;

JENKINSON, HJ ;

MUTTON, IM ;

PEARSON, BA ;

STORER, R ;

CAMERON, JM ;

PENN, CR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (01) :202-205

[8] INHIBITION BY AZIDOTHYMIDINE TRIPHOSPHATE OF REVERSE-TRANSCRIPTASE FROM PAIRED AZT-SUSCEPTIBLE AND AZT-RESISTANT PRIMARY ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].

COX, SW ;

CORRIGAN, G ;

PALMER, S .

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1995, 6 (02) :123-126

[9] TARGETS AND STRATEGIES FOR THE ANTIVIRAL CHEMOTHERAPY OF AIDS [J].

DECLERCQ, E .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (05) :198-205

[10] HIV INHIBITORS TARGETED AT THE REVERSE-TRANSCRIPTASE [J].

DECLERCQ, E .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (02) :119-137

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