Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D

被引：95

作者：

Manning, WC

Paliard, X

Zhou, SZ

Bland, MP

Lee, AY

Hong, K

Walker, CM

Escobedo, JA

Dwarki, V

机构：

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 10期

关键词：

D O I：

10.1128/JVI.71.10.7960-7962.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intramuscular injection of mice with an adeno-associated virus (AAV) vector expressing herpes simplex virus type 2 glycoprotein B led to the generation of both gB-specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes and anti-gB antibody. AAV-mediated immunization was more potent than plasmid DNA or protein in generating antibody responses.

引用

页码：7960 / 7962

页数：3

共 17 条

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