Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins

被引:85
作者
Horwitz, MS [1 ]
机构
[1] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
关键词
E3; proteins; adenovirus; adenoviral vectors; immunomodulation;
D O I
10.1002/jgm.495
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
This manuscript will contain a brief review of adenovirus (Ad) biology including its structure and the spectrum of clinical diseases that it causes. Newer findings about the interactions of Ad early region 3 (E3) proteins with host proteins and signal transduction processes, which control the inflammatory response, will be described. Some of these processes affect the strategies for using Ads as vectors for gene therapy. There are many excellent reviews of some of these aspects [1]. The history of the discoveries that led to the use of Ads as vectors as well as key experiments that resulted in improvements to various aspects of these systems have also been reviewed recently [2]. The use of Ad E3 immunoregulatory genes to facilitate allogeneic transplantation and prevent autoimmune diabetes will be described. Copyright (C) 2004 John Wiley Sons, Ltd.
引用
收藏
页码:S172 / S183
页数:12
相关论文
共 87 条
[1]   Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-γ) [J].
Aradhya, S ;
Courtois, G ;
Rajkovic, A ;
Lewis, RA ;
Levy, M ;
Israël, A ;
Nelson, DL .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (03) :765-771
[2]   Adenovirus type 37 uses sialic acid as a cellular receptor [J].
Arnberg, N ;
Edlund, K ;
Kidd, AH ;
Wadell, G .
JOURNAL OF VIROLOGY, 2000, 74 (01) :42-48
[3]   Reemergence of adenovirus type 4 acute respiratory disease in military trainees: Report of an outbreak during a lapse in vaccination [J].
Barraza, EM ;
Ludwig, SL ;
Gaydos, JC ;
Brundage, JF .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (06) :1531-1533
[4]  
Bennett EM, 1999, J IMMUNOL, V162, P5049
[5]   Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5 [J].
Bergelson, JM ;
Cunningham, JA ;
Droguett, G ;
KurtJones, EA ;
Krithivas, A ;
Hong, JS ;
Horwitz, MS ;
Crowell, RL ;
Finberg, RW .
SCIENCE, 1997, 275 (5304) :1320-1323
[6]   The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses [J].
Bergelson, JM ;
Krithivas, A ;
Celi, L ;
Droguett, G ;
Horwitz, MS ;
Wickham, T ;
Crowell, RL ;
Finberg, RW .
JOURNAL OF VIROLOGY, 1998, 72 (01) :415-419
[7]  
BROKER TR, 1984, PROCESSING RNA, P181
[8]   E3/19K PROTEIN OF ADENOVIRUS TYPE-2 INHIBITS LYSIS OF CYTOLYTIC LYMPHOCYTES-T BY BLOCKING CELL-SURFACE EXPRESSION OF HISTOCOMPATIBILITY CLASS-I ANTIGENS [J].
BURGERT, HG ;
MARYANSKI, JL ;
KVIST, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) :1356-1360
[9]   Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis [J].
Daugas, E ;
Nochy, D ;
Ravagnan, L ;
Loeffler, M ;
Susin, SA ;
Zamzami, N ;
Kroemer, G .
FEBS LETTERS, 2000, 476 (03) :118-123
[10]   X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling [J].
Döffinger, R ;
Smahi, A ;
Bessia, C ;
Geissmann, F ;
Feinberg, J ;
Durandy, A ;
Bodemer, C ;
Kenwrick, S ;
Dupuis-Girod, S ;
Blanche, S ;
Wood, P ;
Rabia, SH ;
Headon, DJ ;
Overbeek, PA ;
Le Deist, F ;
Holland, SM ;
Belani, K ;
Kumararatne, DS ;
Fischer, A ;
Shapiro, R ;
Conley, ME ;
Reimund, E ;
Kalhoff, H ;
Abinun, M ;
Munnich, A ;
Israël, A ;
Courtois, G ;
Casanova, JL .
NATURE GENETICS, 2001, 27 (03) :277-285