Functional conservation of mouse Notch receptor family members

被引：88

作者：

Kato, H

Sakai, T

Tamura, K

Minoguchi, S

Shirayoshi, Y

Hamada, Y

Tsujimoto, Y

Honjo, T

机构：

[1] Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Kyoto 606, Yoshida, Sakyo-ku

[2] National Institute of Genetics, Mishima

[3] Natl. Institute for Basic Biology, Myodaiji, Okazaki

[4] Department of Medical Genetics, Biomedical Research Center, Osaka University Medical School, Suita

来源：

FEBS LETTERS | 1996年 / 395卷 / 2-3期

关键词：

mouse Notch receptor; biochemical function; DNA binding protein interaction;

D O I：

10.1016/0014-5793(96)01046-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All the known members of the mouse Notch receptor family were examined for their biochemical function by interaction with a DNA binding protein RBP-J kappa. mNotch2, mNotch3 and int3 (=mNotch4) mere shown to interact with RBP-J kappa by the GST-fusion pull down assay and dominant negative competition with Epstein Barr virus nuclear antigen 2. Furthermore the intracellular region of int3 was shown to transactivate the Epstein Barr virus TP1 promoter. These results indicate that all mouse Notch family members have biochemical functions similar to mNotch1, which transduces proliferative signal by direct interaction with the DNA binding protein RBP-J kappa.

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页码：221 / 224

页数：4

相关论文

共 26 条

[1] NOTCH SIGNALING [J].

ARTAVANISTSAKONAS, S ;

MATSUNO, K ;

FORTINI, ME .

SCIENCE, 1995, 268 (5208) :225-232

[2] A ZEBRAFISH HOMOLOG OF THE DROSOPHILA NEUROGENIC GENE NOTCH AND ITS PATTERN OF TRANSCRIPTION DURING EARLY EMBRYOGENESIS [J].

BIERKAMP, C ;

CAMPOSORTEGA, JA .

MECHANISMS OF DEVELOPMENT, 1993, 43 (2-3) :87-100

[3] XOTCH, THE XENOPUS HOMOLOG OF DROSOPHILA-NOTCH [J].

COFFMAN, C ;

HARRIS, W ;

KINTNER, C .

SCIENCE, 1990, 249 (4975) :1438-1441

[4] CLONING, ANALYSIS, AND CHROMOSOMAL LOCALIZATION OF NOTCH-1, A MOUSE HOMOLOG OF DROSOPHILA NOTCH [J].

DELAMO, FF ;

GENDRONMAGUIRE, M ;

SWIATEK, PJ ;

JENKINS, NA ;

COPELAND, NG ;

GRIDLEY, T .

GENOMICS, 1993, 15 (02) :259-264

[5] TAN-1, THE HUMAN HOMOLOG OF THE DROSOPHILA NOTCH GENE, IS BROKEN BY CHROMOSOMAL TRANSLOCATIONS IN T-LYMPHOBLASTIC NEOPLASMS [J].

ELLISEN, LW ;

BIRD, J ;

WEST, DC ;

SORENG, AL ;

REYNOLDS, TC ;

SMITH, SD ;

SKLAR, J .

CELL, 1991, 66 (04) :649-661

[6]

GALLAHAN D, 1986, CURR TOP MICROBIOL, V127, P354

[7] MAMMARY TUMORIGENESIS IN FERAL MICE - IDENTIFICATION OF A NEW INT LOCUS IN MOUSE MAMMARY-TUMOR VIRUS (CZECH II)-INDUCED MAMMARY-TUMORS [J].

GALLAHAN, D ;

CALLAHAN, R .

JOURNAL OF VIROLOGY, 1987, 61 (01) :66-74

[8] A NEW COMMON INTEGRATION REGION (INT-3) FOR MOUSE MAMMARY-TUMOR VIRUS ON MOUSE CHROMOSOME-17 [J].

GALLAHAN, D ;

KOZAK, C ;

CALLAHAN, R .

JOURNAL OF VIROLOGY, 1987, 61 (01) :218-220

[9] THE EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-2 TRANSACTIVATOR IS DIRECTED TO RESPONSE ELEMENTS BY THE J-KAPPA RECOMBINATION SIGNAL BINDING-PROTEIN [J].

GROSSMAN, SR ;

JOHANNSEN, E ;

TONG, X ;

YALAMANCHILI, R ;

KIEFF, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7568-7572

[10] MEDIATION OF EPSTEIN-BARR-VIRUS EBNA2 TRANSACTIVATION BY RECOMBINATION SIGNAL-BINDING PROTEIN J(K) [J].

HENKEL, T ;

LING, PD ;

HAYWARD, SD ;

PETERSON, MG .

SCIENCE, 1994, 265 (5168) :92-95