Petrosiols A-E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata

被引：28

作者：

Horikawa, Kouhei ^{[1
]}

Yagyu, Takuya ^{[1
]}

Yoshioka, Yukio ^{[2
]}

Fujiwara, Takeshi ^{[3
]}

Kanamoto, Akihiko ^{[3
]}

Okamoto, Tetsuji ^{[2
]}

Ojika, Makoto ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Hiroshima Univ, Grad Sch Biomed Sci, Hiroshima 7348553, Japan

[3] OP Bio Factory Co Ltd, Naha, Okinawa 9010152, Japan

来源：

TETRAHEDRON | 2013年 / 69卷 / 01期

关键词：

Petrosiols; Sponge; Petrosia strongylata; Neurotrophic activity; PC12; cells; NERVE GROWTH-FACTOR; MARINE SPONGE; STRONGYLOPHORA; DISEASE;

D O I：

10.1016/j.tet.2012.10.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

From an extract of the Okinawan sponge Petrosia strongylata, five novel acetylenic metabolites, petrosiols A (1) E (5), were isolated and chemically characterized. These compounds induced nerve growth factor (NGF)-like neuronal differentiation of PC12 cells. The structure activity relationships of the petrosiols, their derivatives, and some related known compounds suggest the importance of the rare 2,4-diyne-1,6,7,8-tetraol fragment for the neurotrophic activity of the petrosiols. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：101 / 106

页数：6

共 12 条

[1]

AMELIORATION OF CHOLINERGIC NEURON ATROPHY AND SPATIAL MEMORY IMPAIRMENT IN AGED RATS BY NERVE GROWTH-FACTOR [J].

FISCHER, W ;

WICTORIN, K ;

BJORKLUND, A ;

WILLIAMS, LR ;

VARON, S ;

GAGE, FH .

NATURE, 1987, 329 (6134) :65-68

[2]

Linckosides M-Q:: neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata [J].

Han, Chunguang ;

Qi, Jianhua ;

Ojika, Makoto .

JOURNAL OF NATURAL MEDICINES, 2007, 61 (02) :138-145

[3]

Nerve growth factor, neural stem cells and Alzheimer's disease [J].

Heese, Klaus ;

Low, Jin Wei ;

Inoue, Noriko .

NEUROSIGNALS, 2006, 15 (01) :1-12

[4]

Universal NMR databases for contiguous polyols [J].

Higashibayashi, S ;

Czechtizky, W ;

Kobayashi, Y ;

Kishi, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (47) :14379-14393

[5]

THE NERVE GROWTH-FACTOR 35 YEARS LATER [J].

LEVIMONTALCINI, R .

SCIENCE, 1987, 237 (4819) :1154-1162

[6]

HIGH-FIELD FT NMR APPLICATION OF MOSHER METHOD - THE ABSOLUTE-CONFIGURATIONS OF MARINE TERPENOIDS [J].

OHTANI, I ;

KUSUMI, T ;

KASHMAN, Y ;

KAKISAWA, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (11) :4092-4096

[7]

Zooxanthellactone, a novel γ-lactone-type oxylipine from dinoflagellates of Symbiodinium sp.:: Structure, distribution, and biological activity [J].

Onodera, K ;

Fukatsu, T ;

Kawai, N ;

Yoshioka, Y ;

Okamoto, T ;

Nakamura, H ;

Ojika, M .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2004, 68 (04) :848-852

[8]

Qi JH, 2006, CHEMMEDCHEM, V1, P1351, DOI [10.1002/cmdc.200600190, 10.1002/cdmc.200600190]

[9]

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease [J].

Tuszynski, MH ;

Thal, L ;

Pay, M ;

Salmon, DP ;

Sang, UH ;

Bakay, R ;

Patel, P ;

Blesch, A ;

Vahlsing, HL ;

Ho, G ;

Tong, G ;

Potkin, SG ;

Fallon, J ;

Hansen, L ;

Mufson, EJ ;

Kordower, JH ;

Gall, C ;

Conner, J .

NATURE MEDICINE, 2005, 11 (05) :551-555

[10]

Acetylenic strongylodiols from a Petrosia (Strongylophora) Okinawan marine sponge [J].

Watanabe, K ;

Tsuda, Y ;

Hamada, M ;

Omori, M ;

Mori, G ;

Iguchi, K ;

Naoki, H ;

Fujita, T ;

Van Soest, RWM .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (07) :1001-1005

← 1 2 →