NMR structures of damaged DNA

被引：134

作者：

Lukin, M ^{[1
]}

de los Santos, C ^{[1
]}

机构：

[1] SUNY Stony Brook, Sch Med, Dept Pharmacol Sci, Stony Brook, NY 11794 USA

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 02期

关键词：

D O I：

10.1021/cr0404646

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Research in the last two decades has greatly increased knowledge of damaged DNA structure. This bulk of information allowed the identification of common conformational features that describe basic principles of damaged DNA conformation, intermediates of lesion-induced mutagenesis, and lesion recognition by repair proteins. This review covers: abasic sites, DNA nicks, and gaps; oxidative lesions; nucleotide deamination damage; alkylation damage; pyrimidine photo-cross-link products; cross-links induced by platinum compounds; bulky DNA lesions; and nucleotide analogues.

引用

页码：607 / 686

页数：80

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