Opinion - Concomitant regulation of T-cell activation and homeostasis

被引:86
作者
Grossman, Z [1 ]
Min, B
Meier-Schellersheim, M
Paul, WE
机构
[1] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[2] NIAID, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/nri1355
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T cells constitute a heterogeneous, hierarchically organized population, comprising several maturation/differentiation states that have different capacities for clonal expansion and self-renewal. Here, we argue that the relative probabilities of proliferation, differentiation and death - the cellular events that determine the population's structure, as well as its size - are not entirely preprogrammed or fixed; instead, these events are regulated dynamically through the recurrent interaction of lymphocytes with exogenous and endogenous antigens, antigen-presenting cells and each other.
引用
收藏
页码:387 / 395
页数:9
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