Medications for Weight Reduction

被引：15

作者：

Bray, George A. ^{[1
]}

机构：

[1] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2008年 / 37卷 / 04期

关键词：

Sympathomimetic drugs; Lipase inhibitor; Cannabinoid receptor antagonists; Glucagon-like peptide analogues;

D O I：

10.1016/j.ecl.2008.08.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Only two drugs are currently approved for long-term use in the treatment of obesity and four others for short-term use. Evaluating the risk-benefit profile is an essential first step. For individuals who have a low body mass index for whom the risk is small, the risk profile must make the drug acceptable for almost everyone. For higher-risk patients, such as those planning intestinal bypass or who have sleep apnea, a wider range of drugs may be considered. Obesity is a chronic disease that has many causes. Treatment is aimed at palliation-that is, producing and maintaining weight loss. Regardless of the primary site of action, the net effect must be a reduction in food intake or increase in energy expenditure.

引用

页码：923 / +

页数：21

共 88 条

[1] Bupropion SR enhances weight loss: A 48-week double-blind, placebo-controlled trial [J].

Anderson, JW ;

Greenway, FL ;

Fujioka, K ;

Gadde, KM ;

McKenney, J ;

O'Neil, PM .

OBESITY RESEARCH, 2002, 10 (07) :633-641

[2] Long-term maintenance of weight loss after a very-low-calorie diet: A randomized blinded trial of the efficacy and tolerability of sibutramine [J].

Apfelbaum, M ;

Vague, P ;

Ziegler, O ;

Hanotin, C ;

Thomas, F ;

Leutenegger, E .

AMERICAN JOURNAL OF MEDICINE, 1999, 106 (02) :179-184

[3] Topiramate: Long-term maintenance of weight loss induced by a low-calorie diet in obese subjects [J].

Astrup, A ;

Caterson, I ;

Zelissen, P ;

Guy-Grand, B ;

Carruba, M ;

Levy, B ;

Sun, X ;

Fitchet, M .

OBESITY RESEARCH, 2004, 12 (10) :1658-1669

[4] Topiramate: A new potential pharmacological treatment for obesity [J].

Astrup, A ;

Toubro, S .

OBESITY RESEARCH, 2004, 12 :167S-173S

[5] What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions [J].

Avenell, A ;

Brown, TJ ;

McGee, MA ;

Campbell, MK ;

Grant, AM ;

Broom, J ;

Jung, RT ;

Smith, WCS .

JOURNAL OF HUMAN NUTRITION AND DIETETICS, 2004, 17 (04) :293-316

[6] Predictors of weight loss in adults with topiramate-treated epilepsy [J].

Ben-Menachem, E ;

Axelsen, M ;

Johanson, EH ;

Stagge, A ;

Smith, U .

OBESITY RESEARCH, 2003, 11 (04) :556-562

[7] Behavior therapy and sibutramine for the treatment of adolescent obesity - A randomized controlled trial [J].

Berkowitz, RI ;

Wadden, TA ;

Tershakovec, AM ;

Cronquist, JL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (14) :1805-1812

[8] Effects of sibutramine treatment in obese adolescents - A randomized trial [J].

Berkowitz, Robert I. ;

Fujioka, Ken ;

Daniels, Stephen R. ;

Hoppin, Alison G. ;

Owen, Stanford ;

Perry, Arlette C. ;

Sothern, Melinda S. ;

Renz, Cheryl L. ;

Pirner, Mark A. ;

Walch, Julia K. ;

Jasinsky, Olga ;

Hewkin, Ann C. ;

Blakesley, Vicky A. .

ANNALS OF INTERNAL MEDICINE, 2006, 145 (02) :81-90

[9] Sumatriptan decreases food intake and increases plasma growth hormone in healthy women [J].

Boeles, S ;

Williams, C ;

Campling, GM ;

Goodall, EM ;

Cowen, PJ .

PSYCHOPHARMACOLOGY, 1997, 129 (02) :179-182

[10] Current and potential drugs for treatment of obesity [J].

Bray, GA ;

Greenway, FL .

ENDOCRINE REVIEWS, 1999, 20 (06) :805-875

← 1 2 3 4 5 6 7 8 9 →