Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates

被引：38

作者：

Baldanti, F. ^{[1
]}

Paolucci, S. ^{[1
]}

Campanini, G. ^{[1
]}

Sarasini, A. ^{[1
]}

Percivalle, E. ^{[1
]}

Revello, M. G. ^{[1
]}

Gerna, G. ^{[1
]}

机构：

[1] IRCCS, Policlin San Matteo, Serv Virol, I-27100 Pavia, Italy

来源：

ARCHIVES OF VIROLOGY | 2006年 / 151卷 / 06期

关键词：

D O I：

10.1007/s00705-005-0696-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coding sequences of the UL131A, UL130, and UL128 genes of human cytomegalovirus (HCMV) were found to be highly conserved among 34 field isolates from pregnant women with primary HCMV infection and their fetuses or newborns, as well as from solid organ transplant recipients and patients with AIDS. No strain clustering was observed. In contrast, sequencing of UL55 (gB coding gene) allowed the 34 isolates to be clustered into 4 genotypes. The conservation of the UL131A-UL128 locus is consistent with the conclusion that the three encoded proteins are all essential for growth of HCMV in endothelial cells and virus transfer to leukocytes.

引用

页码：1225 / 1233

页数：9

共 22 条

[1] Two novel spliced genes in human cytomegalovirus [J].

Akter, P ;

Cunningham, C ;

McSharry, BP ;

Dolan, A ;

Addison, C ;

Dargan, DJ ;

Hassan-Walker, AF ;

Emery, VC ;

Griffiths, PD ;

Wilkinson, GWG ;

Davison, AJ .

JOURNAL OF GENERAL VIROLOGY, 2003, 84 :1117-1122

[2] Genomes of the endothelial cell-tropic variant and the parental Toledo strain of human cytomegalovirus are highly divergent [J].

Baldanti, F ;

Revello, MG ;

Percivalle, E ;

Labò, N ;

Gerna, G .

JOURNAL OF MEDICAL VIROLOGY, 2003, 69 (01) :76-81

[3]

Benedict CA, 1999, J IMMUNOL, V162, P6967

[4] Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains [J].

Cha, TA ;

Tom, E ;

Kemble, GW ;

Duke, GM ;

Mocarski, ES ;

Spaete, RR .

JOURNAL OF VIROLOGY, 1996, 70 (01) :78-83

[5] ANALYSIS OF INTERSTRAIN VARIATION IN CYTOMEGALOVIRUS GLYCOPROTEIN-B SEQUENCES ENCODING NEUTRALIZATION-RELATED EPITOPES [J].

CHOU, SW ;

DENNISON, KM .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (06) :1229-1234

[6] The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome [J].

Davison, AJ ;

Dolan, A ;

Akter, P ;

Addison, C ;

Dargan, DJ ;

Alcendor, DJ ;

McGeoch, DJ ;

Hayward, GS .

JOURNAL OF GENERAL VIROLOGY, 2003, 84 :17-28

[7] Genetic content of wild-type human cytomegalovirus [J].

Dolan, A ;

Cunningham, C ;

Hector, RD ;

Hassan-Walker, AF ;

Lee, L ;

Addison, C ;

Dargan, DJ ;

McGeoch, DJ ;

Gatherer, D ;

Emery, VC ;

Griffiths, PD ;

Sinzger, C ;

McSharry, BP ;

Wilkinson, GWG ;

Davison, AJ .

JOURNAL OF GENERAL VIROLOGY, 2004, 85 :1301-1312

[8] Human cytomegalovirus replicates abortively in polymorphonuclear leukocytes after transfer from infected endothelial cells via transient microfusion events [J].

Gerna, G ;

Percivalle, E ;

Baldanti, F ;

Sozzani, S ;

Lanzarini, P ;

Genini, E ;

Lilleri, D ;

Revello, MG .

JOURNAL OF VIROLOGY, 2000, 74 (12) :5629-5638

[9] Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells [J].

Gerna, G ;

Percivalle, E ;

Lilleri, D ;

Lozza, L ;

Fornara, C ;

Hahn, G ;

Baldanti, F ;

Revello, MG .

JOURNAL OF GENERAL VIROLOGY, 2005, 86 :275-284

[10] Rescue of human cytomegalovirus strain AD169 tropism for both leukocytes and human endothelial cells [J].

Gerna, G ;

Percivalle, E ;

Sarasini, A ;

Baldanti, F ;

Campanini, G ;

Revello, MG .

JOURNAL OF GENERAL VIROLOGY, 2003, 84 :1431-1436

← 1 2 3 →