Childhood acute lymphoblastic leukaemia with ider(21)(q10)t(12;21)(p12;q22): a new recurrent abnormality showing ETV6/CBFA2 fusion

被引：12

作者：

Andreasson, P ^{[1
]}

Johansson, B ^{[1
]}

Strombeck, B ^{[1
]}

Donner, M ^{[1
]}

Mitelman, F ^{[1
]}

Hoglund, M ^{[1
]}

机构：

[1] UNIV LUND HOSP,DEPT PAEDIAT,S-22185 LUND,SWEDEN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 01期

关键词：

childhood ALL; cytogenetics; FISH; ETV6/CBFA2;

D O I：

10.1046/j.1365-2141.1997.1652982.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cytogenetically unidentifiable t(12;21)(p12;q22), resulting in ETV6/CBFA2 fusion, is the most frequent chromosomal aberration in childhood acute lymphoblastic leukaemia (ALL). We report a variant, ider(21)(q10)t(12;21)(p12;q22), which was shown to contain double ETV6/CBFA2 fusions by fluorescence in situ hybridization. This is the second case of such an ider(21) in childhood ALL, suggesting that it is a new recurrent abnormality. Since the ider(21) is cytogenetically indistinguishable from i(21)(q10) and idic(21)(p11), changes associated with similar clinical features as the t(12;21), i.e. pre-B-cell ALL and age 1-10 years, we suggest that all ALL displaying these changes should be tested for ETV6/CBFA2 fusion transcript.

引用

页码：216 / 218

页数：3

共 13 条

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