The protozoan toxin climacostol inhibits growth and induces apoptosis of human tumor cell lines

被引：35

作者：

Buonanno, Federico ^{[1
,2
]}

Quassinti, Luana ^{[2
]}

Bramucci, Massimo ^{[2
]}

Amantini, Consuelo ^{[3
]}

Lucciarini, Roberta ^{[3
]}

Santoni, Giorgio ^{[3
]}

Iio, Hideo ^{[4
]}

Ortenzi, Claudio ^{[1
,2
]}

机构：

[1] Univ Macerata, Dept Educ Sci, I-62100 Macerata, Italy

[2] Univ Camerino, Dept Mol Cellular & Anim Biol, I-62032 Camerino, Italy

[3] Univ Camerino, Dept Expt Med & Publ Hlth, I-62032 Camerino, Italy

[4] Osaka City Univ, Dept Mat Sci, Osaka 5588585, Japan

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2008年 / 176卷 / 2-3期

关键词：

Climacostol; Cytotoxicity; Anticancer; Apoptosis;

D O I：

10.1016/j.cbi.2008.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Climacostol (5-(Z)-non-2-enyl-benzene-1,3-diol) is a natural toxin isolated from the freshwater ciliated protozoan Climacosmum virens and belongs to the group of resorcinolic lipids, compounds that show antimicrobial, antiparasitic and antitumor activities. We investigated the cytotoxic activity of the chemically synthesized toxin on: (I) human tumor squamous carcinoma A431 cells, (2) human promyelocytic leukaemia HL60 cells, and (3) human non-tumor endothelial EA.hy926 cells. The results showed that climacostol effectively inhibited the growth of tumor cell lines in a dose-dependent manner by inducing programmed cell death, with non-tumor cells proving significantly more resistant to the toxin. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：151 / 164

页数：14

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