Optimization of poly-di-methyl-siloxane (PDMS) substrates for studying cellular adhesion and motility

被引：354

作者：

Fuard, D. ^{[1
]}

Tzvetkova-Chevolleau, T. ^{[1
,2
]}

Decossas, S. ^{[1
]}

Tracqui, P. ^{[2
]}

Schiavone, P. ^{[1
,3
]}

机构：

[1] Lab Technol Microelect, F-38054 Grenoble, France

[2] TIMC IMAG, Fac Med Grenoble, Dynacell Grp, F-38700 La Tronche, France

[3] GMCAO TIMC IMAG, Fac Med Grenoble, F-38700 La Tronche, France

来源：

MICROELECTRONIC ENGINEERING | 2008年 / 85卷 / 5-6期

关键词：

cellular adhesion; cellular motility; PDMS; PDMS youngs's modulus; plastic and elastic deformations; substrate rigidity;

D O I：

10.1016/j.mee.2008.02.004

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The cellular adhesion and motility have direct implications in the tumoral-metastatic cells development or in the tissue engineering mechanisms for instance. Our work aims at knowing the impact of substrate mechanical properties on those adhesion and motility mechanisms by modifying bulk rigidity, surface energy and composition of a bio-compatible poly-di-methyl-siloxane (PDMS) substrate. We show how a wide range of PDMS rigidity can be obtained and how Ar/O-2-based plasmas turn PDMS surface to hydrophilic. A correlation between surface energy, bulk rigidity, cells adhesion and growth is finally shown. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：1289 / 1293

页数：5

共 18 条

[1] Polysilicon gate etching in high density plasmas .2. X-ray photoelectron spectroscopy investigation of silicon trenches etched using a chlorine-based chemistry [J].