Glutaredoxin systems

被引：500

作者：

Lillig, Christopher Horst ^{[1
,2
]}

Berndt, Carsten ^{[1
,2
]}

Holmgren, Arne ^{[1
]}

机构：

[1] Karolinska Inst, Med Nobel Inst Biochem, Dept Med Biochem & Biophys, SE-171777 Stockholm, Sweden

[2] Univ Marburg, Inst Clin Cytobiol & Cytopathol, DE-35037 Marburg, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2008年 / 1780卷 / 11期

基金：

瑞典研究理事会;

关键词：

glutaredoxin; thioredoxin; glutathione; redox control; redox signaling; iron-sulfur cluster; iron homeostasis;

D O I：

10.1016/j.bbagen.2008.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutaredoxins utilize the reducing power of glutathione to maintain and regulate the cellular redox state and redox-dependent signaling pathways, for instance, by catalyzing reversible protein S-glutathionylation. Due to the general importance of these processes, glutaredoxins have been implied in various physiological and disease-related conditions, such as immune defense, cardiac hypertrophy, hypoxia-reoxygenation insult, neurodegeneration and cancer development, progression as well as treatment. The past years have seen an impressive gain of knowledge regarding new glutaredoxin systems and functions. This is true both with respect to new functions in redox regulation and also with respect to unexpected new ties to iron metabolism and iron-sulfur cluster biosynthesis. The aim of this review is to provide a state-of-the-art overview over these recent discoveries with a focus on aspects related to human health. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：1304 / 1317

页数：14

共 199 条

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