Evidence for activation of the renin-angiotensin system in the human prostate:: increased angiotensin II and reduced AT1 receptor expression in prostatic hyperplasia

被引:72
作者
Dinh, DT
Frauman, AG
Somers, GR
Ohishi, M
Zhou, JL
Casley, DJ
Johnston, CI
Fabiani, ME [1 ]
机构
[1] Univ Melbourne, Austin & Repatriat Med Ctr, Dept Med, Clin Pharmacol & Therapeut Unit, Heidelberg, Vic 3084, Australia
[2] Univ Melbourne, Austin & Repatriat Med Ctr, Dept Pathol, Heidelberg, Vic 3084, Australia
[3] Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3010, Australia
关键词
angiotensin II; AT(1) receptors; renin-angiotensin system; human prostate; benign prostatic hyperplasia;
D O I
10.1002/path.1021
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The expression and cellular localization of angiotensin II (Ang II) and AT(1) receptor proteins were examined in the normal human prostate and benign prostatic hyperplasia (BPH) by immunohistochemistry. In the normal prostate, Ang II immunoreactivity was localized to the basal layer of the epithelium and AT(1) receptor immunostaining was found predominantly on stromal smooth muscle and also on vascular smooth muscle of prostatic blood vessels. Ang II immunoreactivity was markedly increased in hyperplastic acini in BPH compared with acini in the normal prostate (normal: 7.4+/-0.2%, n=5 vs. BPH: 22.7+/-1.9%, n=55, p<0.001). However, AT(1) receptor immunoreactivity was significantly decreased in BPH compared with the normal prostate [normal: 16.4+/-2.2%, n=4 vs. BPH: 9.4+/-1.3%, n=5, p<0.05 (p=0.025)]. The present study demonstrates the presence of Ang II peptide in the basal layer of the epithelium and AT(1) receptors on stromal smooth muscle, suggesting that Aug II may mediate paracrine functions on cellular growth and smooth muscle tone in the human prostate. Furthermore, AT(1) receptor down-regulation in BPH may be due to receptor hyperstimulation by increased local levels of Ang II in BPH. These data extend previous findings in support of the novel concept that overactivity of the renin-angiotensin system (RAS) may be involved in the pathophysiology of BPH. Copyright (C) 2001 John Wiley Sons, Ltd.
引用
收藏
页码:213 / 219
页数:7
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