Zhizhu Decoction Promotes Gastric Emptying and Protects the Gastric Mucosa

被引：17

作者：

He, Wei ^{[1
]}

Zhang, Yi ^{[1
]}

Wang, Xinrui ^{[2
]}

Guo, Lingling ^{[3
]}

Han, Lifeng ^{[2
]}

Liu, Erwei ^{[3
]}

Wang, Tao ^{[1
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Minist Educ, Tianjin State Key Lab Modern Chinese Med, Tianjin, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin, Peoples R China

[3] Tianjin Univ Tradit Chinese Med, Key Lab Pharmacol Tradit Chinese Med Formulae, Tianjin, Peoples R China

来源：

JOURNAL OF MEDICINAL FOOD | 2013年 / 16卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Atractylodes macrocephala; Citrus aurantium; gastric emptying; gastric mucosal protection; Zhizhu decoction; FUNCTIONAL DYSPEPSIA; MECHANISM; ULCER; RATS; DOGS;

D O I：

10.1089/jmf.2012.2438

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The aim of this study was to evaluate the effects of the Zhizhu decoction on gastric emptying and gastric mucosal protection. The Zhizhu decoction is composed of Aurantii fructus and Atractylodes macrocephala Rhizoma. Results showed that oral administration of the Zhizhu decoction accelerated gastric emptying in mouse and protected gastric mucosa from ethanol-induced ulcers in rat. Our investigations demonstrated that the Zhizhu decoction accelerated gastric emptying, at least in part, by activating the muscarinic and 5-HT3 receptors. The gastroprotective effect is involved in its antioxidant effects and increased vascular endothelial growth factor expression.

引用

页码：306 / 311

页数：6

共 25 条

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Interobserver variation in the endoscopic diagnosis of gastroduodenal ulcer scars: Implications for clinical management of NSAIDs users [J].