Progress in TiO2 nanotube coatings for biomedical applications: a review

被引：130

作者：

Cheng, Yan ^{[1
]}

Yang, Hui ^{[1
]}

Yang, Yun ^{[2
,3
]}

Huang, Jianying ^{[1
]}

Wu, Ke ^{[4
]}

Chen, Zhong ^{[5
]}

Wang, Xiaoqin ^{[1
]}

Lin, Changjian ^{[2
,3
]}

Lai, Yuekun ^{[1
]}

机构：

[1] Soochow Univ, Coll Text & Clothing Engn, Natl Engn Lab Modern Silk, Suzhou 215123, Peoples R China

[2] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[3] Beijing Naton Technol Grp Co LTD, Beijing Med Implant Engn Res Ctr, Beijing Engn Lab Funct Med Mat & Devices, Beijing 100094, Peoples R China

[4] Xiamen Univ, Affiliated Dongnan Hosp, Dept Cardiol, Zhangzhou 363000, Peoples R China

[5] Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore, Singapore

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 13期

基金：

中国国家自然科学基金;

关键词：

TITANIUM-DIOXIDE NANOTUBES; MESENCHYMAL STEM-CELLS; ENHANCED OSTEOBLAST ADHESION; BONE MORPHOGENETIC PROTEIN-2; SMOOTH-MUSCLE-CELLS; IN-VITRO; ANTIBACTERIAL PROPERTIES; CONTROLLED-RELEASE; NANOWIRE ARRAYS; THIN-FILMS;

D O I：

10.1039/c8tb00149a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Titanium dioxide nanotubes (TNTs) have drawn wide attention and been extensively applied in the field of biomedicine, due to their large specific surface area, good corrosion resistance, excellent biocompatibility, and enhanced bioactivity. This review describes the preparation of TNTs and the surface modification that entrust the nanotubes with better antibacterial property and enhanced osteoblast adhesion, proliferation, and differentiation. Considering the contact between TNTs' surface and surrounding tissues after implantation, the interactions between TNTs (with properties including their diameter, length, wettability, and crystalline phase) and proteins, platelets, bacteria, and cells are illustrated. The state of the art in the applications of TNTs in dentistry, orthopedic implants, and cardiovascular stents are introduced. In particular, the application of TNTs in biosensing has attracted much attention due to its ability for the rapid diagnosis of diseases. Finally, the difficulties and challenges in the practical application of TNTs are also discussed.

引用

页码：1862 / 1886

页数：25

共 280 条

[1]

Inexpensive sol-gel synthesis of multiwalled carbon nanotube-TiO2 hybrids for high performance antibacterial materials [J].