Leukocytapheresis for the treatment of active pouchitis: a pilot study

被引：10

作者：

Araki, Yasumi ^{[2
]}

Mitsuyama, Keiichi ^{[1
]}

Nagae, Takaaki ^{[2
]}

Tou, Yuji ^{[2
]}

Nakagawa, Motonori ^{[2
]}

Iwatani, Yasue ^{[2
]}

Harada, Masakazu ^{[2
]}

Ozasa, Hiroyuki ^{[2
]}

Sata, Michio ^{[1
]}

Noake, Toshihiro ^{[2
]}

机构：

[1] Kurume Univ, Sch Med, Dept Med, Div Gastroenterol, Kurume, Fukuoka 8300011, Japan

[2] Kurume Coloproctol Ctr, Kurume, Fukuoka, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2008年 / 43卷 / 07期

关键词：

ileal pouch-anal anastomosis; leukocytapheresis; pouchitis; ulcerative colitis;

D O I：

10.1007/s00535-008-2199-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background. Pouchitis is a major long-term complication of ileal pouch-anal anastomosis for ulcerative colitis. The aim of this study is to investigate the efficacy of leukocytapheresis for the treatment of active pouchitis. Methods. Eight patients with active pouchitis received leukocytapheresis weekly for 5 weeks in an open-label treatment protocol together with baseline therapy. Results. Patients showed significant improvement in their pouchitis disease activity index scores, from 9.5 (range, 8-10) to 4.0 (range, 2-8) (P < 0.05). Six (75%) of the 8 treated patients achieved remission. No adverse events were observed. Conclusions. Leukocytapheresis therapy could be a new therapeutic strategy for patients with pouchitis after ileal pouch-anal anastomosis for ulcerative colitis. These encouraging results lead us to propose a randomized controlled trial.

引用

页码：571 / 575

页数：5

共 30 条

[1] Pouchitis [J].

Åkerlund, JE ;

Löfberg, R .

CURRENT OPINION IN GASTROENTEROLOGY, 2004, 20 (04) :341-344

[2] Suppression of interleukin-1β- and tumor necrosis factor-α-induced inflammatory responses by leukocytapheresis therapy in patients with ulcerative colitis [J].

Andoh, A ;

Ogawa, A ;

Kitamura, K ;

Inatomi, O ;

Fujino, S ;

Tsujikawa, T ;

Sasaki, M ;

Mitsuyama, K ;

Fujiyama, Y .

JOURNAL OF GASTROENTEROLOGY, 2004, 39 (12) :1150-1157

[3] Pouchitis is associated with mucosal imbalance between interleukin-8 and interleukin-10 [J].

Bulois, P ;

Tremaine, WJ ;

Maunoury, V ;

Gambiez, L ;

Hafraoui, S ;

Leteurtre, E ;

Cortot, A ;

Sandborn, WJ ;

Colombel, JF ;

Desreumaux, P .

INFLAMMATORY BOWEL DISEASES, 2000, 6 (03) :157-164

[4] Assessment of ileoanal pouch inflammation by interleukin 1β and interleukin 8 concentrations in the gut lumen [J].

Evgenikos, N ;

Bartolo, DCC ;

Hamer-Hodges, DW ;

Ghosh, S .

DISEASES OF THE COLON & RECTUM, 2002, 45 (02) :249-255

[5] Leukocytapheresis treatment for pyoderma gangrenosum [J].

Fujimoto, E ;

Fujimoto, N ;

Kuroda, K ;

Tajima, S .

BRITISH JOURNAL OF DERMATOLOGY, 2004, 151 (05) :1090-1092

[6] A case report: First case of filtration leukocytapheresis for a patient of aortitis syndrome associated with ulcerative colitis [J].

Fukunaga, K ;

Sawada, K ;

Fukuda, Y ;

Matoba, Y ;

Onishi, K ;

Fukui, S ;

Yamamura, M ;

Satomi, M ;

Shimoyama, T .

THERAPEUTIC APHERESIS, 2002, 6 (01) :93-98

[7] Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis [J].

Hanai, Hiroyuki ;

Iida, Takayuki ;

Takeuchi, Ken ;

Watanabe, Fumitoshi ;

Maruyama, Yasuhiko ;

Kikuyama, Masataka ;

Tanaka, Tatsuo ;

Kondo, Kenji ;

Tanaka, Kou ;

Takai, Kenji .

WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (20) :3085-3090

[8] Is there a role for apheresis in gastrointestinal disorders? [J].

Hibi, T ;

Sakuraba, A .

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 2005, 2 (05) :200-201

[9]

Hurst RD, 1996, ARCH SURG-CHICAGO, V131, P497

[10] Extracorporeal elimination of TNF-α-producing CD14dullCD16+ monocytes in leukocytapheresis therapy for ulcerative colitis [J].

Kanai, Takanori ;

Makita, Shin ;

Kawamura, Takahiro ;

Nemoto, Yasuhiro ;

Kubota, Daisuke ;

Nagayama, Kazuyoshi ;

Totsuka, Teruji ;

Watanabe, Mamoru .

INFLAMMATORY BOWEL DISEASES, 2007, 13 (03) :284-290

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