Phospholipase D and membrane traffic - Potential roles in regulated exocytosis, membrane delivery and vesicle budding

被引：149

作者：

Jones, D ^{[1
]}

Morgan, C ^{[1
]}

Cockcroft, S ^{[1
]}

机构：

[1] UCL, Dept Physiol, London WC1E 6JJ, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1999年 / 1439卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

exocytosis; membrane trafficking; vesicle budding;

D O I：

10.1016/S1388-1981(99)00097-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is now well-established that phospholipase D is transiently stimulated upon activation by G-protein-coupled and receptor tyrosine kinase cell surface receptors in mammalian cells. Over the last 5 years, a tremendous effort has gone to identify the major intracellular regulators of mammalian phospholipase D and to the cloning of two mammalian phospholipase D enzymes (phospholipase D1 and D2). In this chapter, we review the physiological function of mammalian phospholipase D1 that is synergistically stimulated by ADP ribosylation factor, Rho and protein kinase Ca. We discuss the function of this enzyme in membrane traffic, emphasising the possible integrated relationships between consumption of vesicles in regulated exocytosis, membrane delivery and constitutive membrane traffic. (C) 1999 Elsevier Science B.V, All rights reserved.

引用

页码：229 / 244

页数：16

共 132 条

[1]

AMOR JC, 1994, NATURE, V372, P704, DOI 10.1038/372704a0

[2] N-terminal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchange [J].