Long-term immunogenicity and safety of an inactivated hepatitis A vaccine in haemophilic patients

被引:9
作者
Dentico, P
Ciavarella, N
Scaraggi, FA
Schiavoni, M
Volpe, A
Fasano, A
Perricci, A
Buongiorno, R
机构
[1] UNIV BARI,DEPT INTERNAL MED & INFECT DIS,COAGULAT SERV,BARI,ITALY
[2] UNIV BARI,HAEMOPHILIA CTR,BARI,ITALY
[3] UNIV BARI,HAEMOSTASIS & THROMBOSIS LAB,BARI,ITALY
关键词
HAV; HAV vaccine; HIV; haemophiliacs; inactivated vaccine; vaccine;
D O I
10.1111/j.1365-2516.1996.tb00008.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
As a consequence of recent outbreaks of HAV infection by blood products, 91 patients, haemophiliacs and subjects with bleeding disorders (10 of whom were also anti-HIV positive) susceptible to HAV infection received a formalin-inactivated hepatitis A vaccine (HAVRIX 720 Elisa Units, SmithKline Beecham). Subcutaneous injections were given in the deltoid region at 0, 1 and 6 months. The seroconversion rates and titres, expressed in GMT IU/I, were determined at 1, 2, 6, 7, 12, 18 and 24 months. No adverse reactions to the vaccine were observed. The highest percentage of responders observed was 98.7% in anti-HIV negative and 71.4% in anti-HIV positive patients. The anti-HAV GMT titres were higher in anti-HIV negative than in anti-HIV positive patients. The inactivated hepatitis A vaccine is safe, clinically well tolerated, and provides long-term protection against HAV infection.
引用
收藏
页码:37 / 40
页数:4
相关论文
共 18 条
[1]  
AMBROSCH F, 1991, VIRAL HEPATITIS LIVE
[2]  
CUHEN J, 1989, J INFECT DIS, V160, P887
[3]   ACUTE HEPATITIS-A IN HEMOPHILIACS [J].
GERRITZEN, A ;
SCHNEWEIS, KE ;
BRACKMANN, HH ;
OLDENBURG, J ;
HANFLAND, P ;
GERLICH, WH ;
CASPARI, G .
LANCET, 1992, 340 (8829) :1231-1232
[4]   TRANSFUSION-ACQUIRED HEPATITIS-A OUTBREAK FROM FRESH-FROZEN PLASMA IN A NEONATAL INTENSIVE-CARE UNIT [J].
LEE, KK ;
VARGO, LR ;
LE, CT ;
FERNANDO, L .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1992, 11 (02) :122-123
[5]   TYPE-A VIRAL-HEPATITIS - NEW DEVELOPMENTS IN AN OLD DISEASE [J].
LEMON, SM .
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (17) :1059-1067
[6]   TRANSMISSION OF HEPATITIS-A TO PATIENTS WITH HEMOPHILIA BY FACTOR-VIII CONCENTRATES TREATED WITH ORGANIC-SOLVENT AND DETERGENT TO INACTIVATE VIRUSES [J].
MANNUCCI, PM ;
GDOVIN, S ;
GRINGERI, A ;
COLOMBO, M ;
MELE, A ;
SCHINAIA, N ;
CIAVARELLA, N ;
EMERSON, SU ;
PURCELL, RH .
ANNALS OF INTERNAL MEDICINE, 1994, 120 (01) :1-7
[7]   OUTBREAK OF HEPATITIS-A AMONG ITALIAN PATIENTS WITH HEMOPHILIA [J].
MANNUCCI, PM .
LANCET, 1992, 339 (8796) :819-819
[8]   LONG-TERM IMMUNOGENICITY OF A PLASMA-DERIVED HEPATITIS-B VACCINE IN HIV SEROPOSITIVE AND HIV SERONEGATIVE HEMOPHILIACS [J].
MANNUCCI, PM ;
ZANETTI, AR ;
GRINGERI, A ;
TANZI, E ;
MORFINI, M ;
MESSORI, A ;
TIRINDELLI, MC ;
DEBIASI, R ;
CIAVARELLA, N ;
COLOMBO, M .
ARCHIVES OF INTERNAL MEDICINE, 1989, 149 (06) :1333-1337
[9]  
MELE A, 1991, ITAL J GASTROENTEROL, V23, P341
[10]   IMMUNE-RESPONSE OF PATIENTS WITH CONGENITAL COAGULATION DISORDERS TO HEPATITIS-B VACCINE - SUBOPTIMAL RESPONSE AND HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].
MILLER, EJ ;
LEE, CA ;
KARAYIANNIS, P ;
HOLMES, S ;
THOMAS, HC ;
KERNOFF, PBA .
JOURNAL OF MEDICAL VIROLOGY, 1989, 28 (02) :96-100