PTPN22 C1858T polymorphism and human brucellosis

被引：7

作者：

Bravo, Maria Jose ^{[1
,5
]}

Colmenero, Juan Dios ^{[2
]}

Queipo-Ortuno, Maria Isabel ^{[1
,3
]}

Morata, Pilar ^{[3
]}

Orozco, Gisela ^{[4
]}

Martin, Javier ^{[4
]}

Alonso, Antonio ^{[5
]}

Caballero, Abelardo ^{[5
]}

机构：

[1] Imabis Fdn, Malaga, Spain

[2] Carlos Haya Hosp, Infect Dis Serv, Malaga, Spain

[3] Fac Med, Dept Biochem & Mol Biol, Malaga, Spain

[4] Lopez Neyra Parasitol & Biomed Inst, Granada, Spain

[5] Carlos Haya Hosp, Serv Immunol, Malaga, Spain

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2009年 / 41卷 / 02期

关键词：

LYMPHOID TYROSINE PHOSPHATASE; SINGLE-NUCLEOTIDE POLYMORPHISM; RHEUMATOID-ARTHRITIS; GENE; DISEASE; VARIANT; LYP;

D O I：

10.1080/00365540802641864

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The PTPN22 gene encodes for an intracellular lymphoid-specific phosphatase (Lyp) that has a negative regulatory effect on T-cell activation. The minor allele of the single nucleotide polymorphism (SNP) in the PTPN22 gene encoding the Lyp-tyrosine phosphatase has been associated with multiple autoimmune disorders and with susceptibility to M. tuberculosis. It is possible, therefore, that variants of this gene may also be involved in susceptibility to another intracellular pathogen, B. melitensis, which gives rise to human brucellosis. Accordingly, we studied 111 patients with brucellosis and 150 healthy controls who had had no prior contact with the pathogen. Genotyping of the PTPN22 1858CT was performed by an allele discrimination assay with TaqMan 5'. We found no statistically significant differences between the patients and the controls in genotype or allele frequencies of PTPN22 1858CT. These data suggest that this variant is not associated with human brucellosis.

引用

页码：109 / 112

页数：4

共 19 条

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