Separation of DL-dopa by means of micellar electrokinetic capillary chromatography after derivatization with Marfey's reagent

被引：7

作者：

Wu, G

Furlanut, M

机构：

[1] Ist. di Farmacol. Clin. e T., Facoltà di Med. e Chirurgia, Universita degli Studi di Udine, 33100 Udine, P. le S. Maria della Misericordia

来源：

PHARMACOLOGICAL RESEARCH | 1997年 / 35卷 / 06期

关键词：

levodopa; dextrodopa; DL-3-O-methyl-dopa; micellar electrokinetic capillary chromatography;

D O I：

10.1006/phrs.1997.0192

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Micellar electrokinetic capillary chromatography was used to separate levodopa(L-3,4-dihydroxyphenyl-L-alanine), dextrodopa (D-3,4-dihydroxyphenyl-L-alanine) and DL-3-O-methyl-dopa, a metabolite of dopa, which were derivatised with the Marfey's reagent, in sodium berate, sodium dodecyl sulfate and acetonitile buffer system. Whereas DL-dopa derivatives could be separated, DL-3-O-methyl-dopa derivatives could not. (C) 1997 The Italian Pharmacological Society.

引用

页码：553 / 556

页数：4

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