Regenerating gene expression in normal gastric mucosa and indomethacin-induced mucosal lesions of the rat

被引：68

作者：

Kawanami, C ^{[1
]}

Fukui, H ^{[1
]}

Kinoshita, Y ^{[1
]}

Nakata, H ^{[1
]}

Asahara, M ^{[1
]}

Matsushima, Y ^{[1
]}

Kishi, K ^{[1
]}

Chiba, T ^{[1
]}

机构：

[1] KYOTO UNIV,GRAD SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL & HEPATOL,SAKYO KU,KYOTO 60601,JAPAN

来源：

JOURNAL OF GASTROENTEROLOGY | 1997年 / 32卷 / 01期

关键词：

stomach; gastric ulcer; mucosal healing; growth factor; c-fos;

D O I：

10.1007/BF01213290

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Regenerating (reg) gene expression was tested in rat gastrointestinal mucosa to investigate the role played by this gene in the healing of mucosal lesions, Expression of reg mRNA was higher in the stomach than in any other region of the gastrointestinal tract. The gastric cells that expressed reg mRNA were located in the deepest mucosal layer and were small in diameter. In an injured state following indomethacin treatment, reg gene expression was markedly augmented, accompanied by an increase of c-fos expression and healing of the mucosal lesions. These results suggest a role of the reg gene in the healing of gastrointestinal mucosal lesions.

引用

页码：12 / 18

页数：7

共 25 条

[1]

GASTRIN RECEPTOR GENES ARE EXPRESSED IN GASTRIC PARIETAL AND ENTEROCHROMAFFIN-LIKE CELLS OF MASTOMYS-NATALENSIS [J].