5-HTTLPR variants not associated with autistic spectrum disorders

被引：60

作者：

Zhong, N

Ye, LL

Ju, WN

Tsiouris, J

Cohen, I

Brown, WT

机构：

[1] New York State Inst Basic Res Dev Disabil, Dept Human Genet, Staten Isl, NY 10314 USA

[2] New York State Inst Basic Res Dev Disabil, George A Jervis Clin, Staten Isl, NY 10314 USA

来源：

NEUROGENETICS | 1999年 / 2卷 / 02期

关键词：

autism; serotonin transporter; genotypes; polymorphism; fragile X syndrome;

D O I：

10.1007/s100480050064

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To determine whether there is an association of polymorphic variants of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) and autistic spectrum disorders, we analyzed the 5-HTTLPR genotypes of 72 autistic subjects, 11 fragile X syndrome patients with autistic behavior, 43 normal subjects, and 49 fragile X syndrome non-autistic subjects. The distribution frequency of 5-HTTLPR long allele (L) and the short allele (S) variants showed no differences between subjects. Our findings do not support the hypothesis that polymorphic 5-HTTLPR variants are a susceptibility factor for autistic disorders.

引用

页码：129 / 131

页数：3

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