Rapid-setting, mesoporous, bioactive glass cements that induce accelerated in vitro apatite formation

被引:116
作者
Shi, QH
Wang, JF
Zhang, JP
Fan, J
Stucky, GD [1 ]
机构
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
[2] Chinese Univ Hong Kong, Dept Phys, Shatin, Hong Kong, Peoples R China
[3] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA
关键词
D O I
10.1002/adma.200502292
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A rapid-setting, mesoporous, bioactive glass cement (MBGC, see figure) that exhibits highly desirable plasticity and superior in vitro bioactivity is described. The calcium-deficient hydroxyapatite nanocrystals that form during cement setting act as linkers between mesoporous bioactive glass particles to make the cement mechanically robust. The MGBC is promising for applications in clinical orthopedics, drug delivery, and tissue engineering.
引用
收藏
页码:1038 / +
页数:6
相关论文
共 54 条
[1]   Control of crystal nucleation by patterned self-assembled monolayers [J].
Aizenberg, J ;
Black, AJ ;
Whitesides, GM .
NATURE, 1999, 398 (6727) :495-498
[2]   Direct fabrication of large micropatterned single crystals [J].
Aizenberg, J ;
Muller, DA ;
Grazul, JL ;
Hamann, DR .
SCIENCE, 2003, 299 (5610) :1205-1208
[3]  
AOKI H, 1994, MED APPL HYDROXYAPAT, P58
[4]  
Brinker CJ, 1999, ADV MATER, V11, P579, DOI 10.1002/(SICI)1521-4095(199905)11:7<579::AID-ADMA579>3.3.CO
[5]  
2-I
[6]   Premixed rapid-setting calcium phosphate composites for bone repair [J].
Carey, LE ;
Xu, HHK ;
Simon, CG ;
Takagi, S ;
Chow, LC .
BIOMATERIALS, 2005, 26 (24) :5002-5014
[7]   Preparation of hydroxyapatite-gelatin nanocomposite [J].
Chang, MC ;
Ko, CC ;
Douglas, WH .
BIOMATERIALS, 2003, 24 (17) :2853-2862
[8]  
Chow LC, 2000, J BIOMED MATER RES, V53, P511, DOI 10.1002/1097-4636(200009)53:5<511::AID-JBM10>3.3.CO
[9]  
2-5
[10]  
CHOW LC, 1991, NIPPON SERAM KYO GAK, V99, P954