Synthesis of medium-ring lactones via tandem methylenation/Claisen rearrangement of cyclic carbonates

被引:34
作者
Anderson, EA
Davidson, JEP
Harrison, JR
O'Sullivan, PT
Burton, JW
Collins, I
Holmes, AB
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England
基金
英国工程与自然科学研究理事会;
关键词
medium-ring; lactone; Claisen rearrangement; carbonate; dimethyltitanocene;
D O I
10.1016/S0040-4020(02)00049-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The conversion of vinyl-substituted 6- and 7-membered cyclic carbonates into 8- and 9-membered medium-ring lactones has been achieved in good yield using dimethyltitanocene in toluene at reflux. The reaction proceeds by initial formation of a ketene acetal which undergoes subsequent in situ Claisen rearrangement to provide the corresponding lactones. The preparation of the cyclic carbonates is carried out under basic conditions and hence this methodology complements our existing selenium-based methodology for the synthesis of medium-ring lactones. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码:1943 / 1971
页数:29
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