Pharmacological approaches to restore mitochondrial function

被引：310

作者：

Andreux, Penelope A. ^{[1
]}

Houtkooper, Riekelt H. ^{[2
]}

Auwerx, Johan ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, CH-1015 Lausanne, Switzerland

[2] Univ Amsterdam, Acad Med Ctr, Lab Genet & Metab Dis, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE REVIEWS DRUG DISCOVERY | 2013年 / 12卷 / 06期

基金：

瑞士国家科学基金会; 美国国家卫生研究院;

关键词：

CYTOCHROME-C-OXIDASE; TRANSCRIPTIONAL COREPRESSOR RIP140; SMALL-MOLECULE ACTIVATORS; GENOME-WIDE ASSOCIATION; HUMAN SKELETAL-MUSCLE; FATTY-ACID OXIDATION; LIFE-SPAN EXTENSION; PPAR-GAMMA LIGAND; RECEPTOR-ALPHA; ERR-ALPHA;

D O I：

10.1038/nrd4023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but also implicated in age-related diseases, including those that affect the metabolic and nervous system, such as type 2 diabetes and Parkinson's disease. Numerous pathways maintain and/or restore proper mitochondrial function, including mitochondrial biogenesis, mitochondrial dynamics, mitophagy and the mitochondrial unfolded protein response. New and powerful phenotypic assays in cell-based models as well as multicellular organisms have been developed to explore these different aspects of mitochondrial function. Modulating mitochondrial function has therefore emerged as an attractive therapeutic strategy for several diseases, which has spurred active drug discovery efforts in this area.

引用

页码：465 / 483

页数：19

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