Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patients

被引：13

作者：

Blandizzi, C

Malizia, T

Batoni, G

Ghelardi, E

Baschiera, F

Bruschini, P

Senesi, S

Campa, M

Del Tacca, M

机构：

[1] Univ Hosp Pisa, Dept Oncol Transplants & Adv Technol Med, Div Pharmacol & Chemotherapy, Pisa, Italy

[2] Univ Hosp Pisa, Dept Expt Pathol Med Biotechnol Infect Dis & Epid, Microbiol Sect, Pisa, Italy

[3] Univ Hosp Pisa, Div Otorhinolaryngol, Pisa, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 05期

关键词：

D O I：

10.1128/AAC.46.5.1594-1596.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.

引用

页码：1594 / 1596

页数：3

共 15 条

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