Microbicides and other topical strategies to prevent vaginal transmission of HIV

被引：158

作者：

Lederman, MM

Offord, RE

Hartley, O

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44106 USA

[2] Mintaka Fdn Med Res, CH-1228 Geneva, Switzerland

[3] Ctr Med Univ Geneva, Dept Struct Biol & Bioinformat, CH-1211 Geneva 4, Switzerland

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1848

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HIV epidemic is, by many criteria, the worst outbreak of infectious disease in history. The rate of new infections is now similar to 5 million per year, mainly in the developing world, and is increasing. Women are now substantially more at risk of infection with HIV than men. With no cure or effective vaccine in sight, a huge effort is required to develop topical agents ( often called microbicides) that, applied to the vaginal mucosa, would prevent infection of these high-risk individuals. We discuss the targets for topical agents that have been identified by studies of the biology of HIV infection and provide an overview of the progress towards the development of a usable agent.

引用

收藏

页码：371 / 382

页数：12

相关论文

共 129 条

[1] Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infection [J].

Abel, K ;

Rocke, DM ;

Chohan, B ;

Fritts, L ;

Miller, CJ .

JOURNAL OF VIROLOGY, 2005, 79 (19) :12164-12172

[2] Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation [J].

Agace, WW ;

Amara, A ;

Roberts, AI ;

Pablos, JL ;

Thelen, S ;

Uguccioni, M ;

Li, XY ;

Marsal, J ;

Arenzana-Seisdedos, F ;

Delaunay, T ;

Ebert, EC ;

Moser, B ;

Parker, CM .

CURRENT BIOLOGY, 2000, 10 (06) :325-328

[3] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].

Alkhatib, G ;

Combadiere, C ;

Broder, CC ;

Feng, Y ;

Kennedy, PE ;

Murphy, PM ;

Berger, EA .

SCIENCE, 1996, 272 (5270) :1955-1958

[4] HIV coreceptor downregulation as antiviral principle: SDF-1 alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication [J].

Amara, A ;

LeGall, S ;

Schwartz, O ;

Salamero, J ;

Montes, M ;

Loetscher, P ;

Baggiolini, M ;

Virelizier, JL ;

ArenzanaSeisdedos, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (01) :139-146

[5] HIV blocked by chemokine antagonist [J].

ArenzanaSeisdedos, F ;

Virelizier, JL ;

Rousset, D ;

ClarkLewis, I ;

Loetscher, P ;

Moser, B ;

Baggiolini, M .

NATURE, 1996, 383 (6599) :400-400

[6] Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 trial [J].

Auvert, B ;

Taljaard, D ;

Lagarde, E ;

Sobngwi-Tambekou, J ;

Sitta, M ;

Puren, A .

PLOS MEDICINE, 2005, 2 (11) :1112-1122

[7] A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity [J].

Baba, M ;

Nishimura, O ;

Kanzaki, N ;

Okamoto, M ;

Sawada, H ;

Iizawa, Y ;

Shiraishi, M ;

Aramaki, Y ;

Okonogi, K ;

Ogawa, Y ;

Meguro, K ;

Fujino, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) :5698-5703

[8] Concern voiced over "dry sex" practices in South Africa [J].

Baleta, A .

LANCET, 1998, 352 (9136) :1292-1292

[9] ALPHA-(1-3)-D-MANNOSE-SPECIFIC AND ALPHA-(1-6)-D-MANNOSE-SPECIFIC PLANT-LECTINS ARE MARKEDLY INHIBITORY TO HUMAN-IMMUNODEFICIENCY-VIRUS AND CYTOMEGALOVIRUS INFECTIONS INVITRO [J].

BALZARINI, J ;

SCHOLS, D ;

NEYTS, J ;

VANDAMME, E ;

PEUMANS, W ;

DECLERCQ, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (03) :410-416

[10] THE MANNOSE-SPECIFIC PLANT-LECTINS FROM CYMBIDIUM HYBRID AND EPIPACTIS-HELLEBORINE AND THE (N-ACETYLGLUCOSAMINE)N-SPECIFIC PLANT LECTIN FROM URTICA-DIOICA ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS AND CYTOMEGALOVIRUS REPLICATION INVITRO [J].

BALZARINI, J ;

NEYTS, J ;

SCHOLS, D ;

HOSOYA, M ;

VANDAMME, E ;

PEUMANS, W ;

DECLERCQ, E .

ANTIVIRAL RESEARCH, 1992, 18 (02) :191-207

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