Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group

被引:1982
作者
Rodeghiero, Francesco [1 ]
Stasi, Roberto [2 ]
Gernsheimer, Terry [3 ]
Michel, Marc [4 ]
Provan, Drew [5 ]
Arnold, Donald M. [6 ]
Bussel, James B. [7 ]
Cines, Douglas B. [8 ]
Chong, Beng H. [9 ,10 ]
Cooper, Nichola [11 ]
Godeau, Bertrand [4 ]
Lechner, Klaus [12 ]
Mazzucconi, Maria Gabriella [13 ]
McMillan, Robert [14 ]
Sanz, Miguel A. [15 ]
Imbach, Paul [16 ]
Blanchette, Victor [17 ]
Kuehne, Thomas [17 ]
Ruggeri, Marco [1 ]
George, James N. [18 ]
机构
[1] San Bortolo Hosp, Dept Hematol, I-36100 Vicenza, Italy
[2] Osped Regina Apostolorum, Dept Med Sci, Albano Laziale, Italy
[3] Univ Washington, Sch Med, Puget Sound Blood Ctr, Seattle, WA USA
[4] Univ Paris 12, Hop Henri Mondor, AP HP, Fac Med,Serv Med Interne, F-94010 Creteil, France
[5] Barts & London Queen Marys Sch Med & Dent, Dept Haematol, London, England
[6] McMaster Univ, Dept Med, Michael G DeGroote Sch Med, Hamilton, ON, Canada
[7] Cornell Univ, Weill Cornel Med Coll, New York, NY 10021 USA
[8] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[9] Univ New S Wales, Dept Hematol, St George Hosp, S Eastern Area Lab Serv, Sydney, NSW, Australia
[10] Univ New S Wales, Dept Med, St George Clin Sch, Sydney, NSW, Australia
[11] Inst Child Hlth, Mol Immunol Unit, London, England
[12] Med Univ Vienna, Div Haematol & Haemostaseol, Dept Internal Med 1, Vienna, Austria
[13] Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy
[14] Scripps Res Inst, La Jolla, CA USA
[15] Hosp Univ La Fe, Hematol Serv, Valencia, Spain
[16] Univ Basel, Childrens Hosp, Basel, Switzerland
[17] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Hematol Oncol, Toronto, ON M5G 1X8, Canada
[18] Univ Oklahoma Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Hematol Oncol Sect,Coll Med, Oklahoma City, OK USA
关键词
QUALITY-OF-LIFE; HELICOBACTER-PYLORI ERADICATION; INTRAVENOUS IMMUNOGLOBULIN-G; HIGH-DOSE METHYLPREDNISOLONE; RANDOMIZED-TRIAL; ANTI-D; ORAL PREDNISONE; PLATELET COUNT; REFERENCE VALUES; CHILDHOOD-ITP;
D O I
10.1182/blood-2008-07-162503
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diagnosis and management of immune thrombocytopenic purpura (ITP) remain largely dependent on clinical expertise and observations more than on evidence derived from clinical trials of high scientific quality. One major obstacle to the implementation of such studies and in producing reliable meta-analyses of existing data is a lack of consensus on standardized critical definitions, outcome criteria, and terminology. Moreover, the demand for comparative clinical trials has dramatically increased since the introduction of new classes of therapeutic agents, such as thrombopoietin receptor agonists, and innovative treatment modalities, such as anti-CD 20 antibodies. To overcome the present heterogeneity, an International Working Group of recognized expert clinicians convened a 2-day structured meeting (the Vicenza Consensus Conference) to define standard terminology and definitions for primary ITP and its different phases and criteria for the grading of severity, and clinically meaningful outcomes and response. These consensus criteria and definitions could be used by investigational clinical trials or cohort studies. Adoption of these recommendations would serve to improve communication among investigators, to enhance comparability among clinical trials, to facilitate meta-analyses and development of therapeutic guidelines, and to provide a standardized framework for regulatory agencies. (Blood. 2009; 113: 2386-2393)
引用
收藏
页码:2386 / 2393
页数:8
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